EP300

 

   

OMIM :  602700

GENECARD : EP300

CGAP : 25272

 

 

SYNONYMS

  • p300

  • E1A binding protein p300

 

 

Function 

Mutations truncating the EP300 acetylase in human cancers. Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin SF, Daigo Y, Russell P, Wilson A, Sowter HM, Delhanty JD, Ponder BA, Kouzarides T, Caldas C.

 

 

Tumor Gene Type 

EP300 is mutated in epithelial cancers and provide the first evidence that it behaves as a classical tumour-suppressor gene. Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin SF, Daigo Y, Russell P, Wilson A, Sowter HM, Delhanty JD, Ponder BA, Kouzarides T, Caldas C.