OMIM : 147545
GENECARD : IRS1
CGAP : 96063
SYNONYMS
Biochemical type
IRS molecules act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R.
Insulin receptor substrate-1 (IRS-1) is a multisite docking protein. Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M.
Oncogenicity
Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M.
Function
Insulin receptor substrate-1 (IRS-1) is a multisite docking protein implicated in mitogenic signaling following activation of the insulin and insulin-like growth factor I receptors. Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M.