[BiO BB] hi

[Pankaj]

hi all,
i m a new member of this board.
i have a 3 protein structures (all taking the same fold) with the
substrate bound. the residues surrounding the substrate are the active
site residues. now i have a set of 400 protein sequences which i know
take the same above mentioned fold. i want to extract the active site
residues from these 400 sequences. but whatever alignment program i
use either uses only sequence information or only structure
information. is there an alignment program which can use both
structure and sequence information for the alignment of these 400
sequences on the strcutural template