[Bioclusters] Re: Help on BLAST

[Wim Glassee]

Hej Lai,

The NCBI Blast course found on their website:
http://www.ncbi.nlm.nih.gov/BLAST/tutorial/Altschul-1.html

Wim

Wim Glassee - BioInformatics Unit - Molecular Genetics Group -
Department of BioChemistry - University of Antwerp - BELGIUM - email:
wim.glassee@ua.ac.be


> -----Original Message-----
> From: bioclusters-admin@bioinformatics.org [mailto:bioclusters-
> admin@bioinformatics.org] On Behalf Of Lai Loong Fong
> Sent: woensdag 28 augustus 2002 3:22
> To: bioclusters@bioinformatics.org
> Subject: RE: [Bioclusters] Re: Help on BLAST
> 
> At 11:18 AM 27/8/2002 +0200, you wrote:
> >Hi Chris,
> >
> > >
> > >
> > > Wim,
> > >
> > > If you assume that the two blast target sets are non-overlapping,
the
> > > only scores which need to be recalculated are the e- and p-
values.
> > > Score and Bit Score are based soley on the alignment, substitution
> > > matrix, and gap costs, plus the K and lambda parameters.  Those
don't
> > > change with target set size.
> > >
> > >   e-value = { m n 2^(bit_score) }
> >
> >Shouldn't this be:
> >
> >         e-value = { m n 2^(-bit_score) }
> >
> >I think you forgot a minus. This is the equation found in the blast
> >tutorial.
> Hi Wim,
> May I know which blast tutorial are you referring to here?
> 
> Lai L F
> 
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