[Bioclusters] Announcing ThermonucleotideBLAST
Jason Gans
jgans at lanl.gov
Tue Nov 27 15:21:51 EST 2007
ThermonucleotideBLAST is a software program for searching a target
database of nucleic acid sequences using queries based biochemical
assays (i.e. a pair of oligonucleotide sequences representing PCR
primers or Padlock probes, a triplet of oligos representing PCR primers
and a TaqMan probe or a single oligo representing a hybridization
probe).
ThermonucleotideBLAST uses physically relevant measures of sequence
similarity (free energy and/or melting temperature) to identify matches
between a query and target sequence.
To enable searching of very large sequence databases,
ThermonucleotideBLAST uses run-time database and query segmentation to
distribute the computational load across multiple CPUs (using either
MPI or OpenMP). Supported platforms include Linux, OS X and Windows.
The source code is freely available (BSD license) from
http://snp.lanl.gov/tntblast
Regards,
Jason Gans
Bioscience Division
Los Alamos National Laboratory
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