From gerard at xray.bmc.uu.se Wed Sep 14 11:57:52 2011 From: gerard at xray.bmc.uu.se (Gerard DVD Kleywegt) Date: Wed, 14 Sep 2011 17:57:52 +0200 (CEST) Subject: [ssml] Quips about greasy pockets Message-ID: Hi all, As you may recall, the Protein Data Bank in Europe (PDBe; pdbe.org) regularly produces Quips, short stories about QUite Interesting Pdb Structures (pdbe.org/quips). Quips address biologically interesting aspects of one or more PDB entries, coupled with interactive graphics views and often a mini-tutorial or suggestions for further exploration using PDBe services and resources. Today another Quips episode was released. It is about autotaxins, physiologically important proteins that are pursued as anti-cancer drug targets. This Quips was developed together with scientists from the Netherlands Cancer Institute (Tassos Perrakis and Wouter Moolenaar) to accompany their review paper in Nature Reviews Molecular Cell Biology on autotaxin structure and function that was also published today. - For the Quips story ("Autotaxins: inhibiting a greasy pocket"), go to: http://pdbe.org/quips?story=Autotaxin - For the review paper ("Insights into autotaxin: how to produce and present a lipid mediator"), go to: http://www.nature.com/nrm/journal/vaop/ncurrent/full/nrm3188.html --- If you have an interesting structure whose story you would like to tell (with our help) in the form of a Quips episode, please contact us at pdbe at ebi.ac.uk --Gerard --- Gerard J. Kleywegt, PDBe, EMBL-EBI, Hinxton, UK gerard at ebi.ac.uk ..................... pdbe.org Secretary: Pauline Haslam pdbe_admin at ebi.ac.uk