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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
Smad4 Smad2 interact1 Phosphorylation at both sites is required to mediate association of Smad2 with Smad4 in mammalian cells , while in yeast , Smad2 interacts directly with Smad4 and does not require phosphorylation . 21 good bad
Smad4 MAD complex3 MEDEA is most similar to mammalian Smad4 and forms heteromeric complexes with MAD . 18 good bad
Smad4 p16 associate3 CONCLUSIONS : These data indicate that loss of p16 ( INK4A ) and Smad4 expression occur more frequently in IPMC alone , or with associated invasive carcinoma , compared with adenoma borderline IPMT . 18 good bad
Smad4 p38 associate1 Our findings demonstrate that ( i ) decrease of Smad4 mRNA expression is closely associated with defective TGF-beta response and lack of growth inhibition , ( ii ) activation of PAI-1 by TGF-beta may 18 good bad
Smad4 Activin associate1 Activin stimulation triggered association of Dok-1 with Smad3 , as well as association of Smad3 with Smad4 . 17 good bad
Smad4 Smad bind1 While there are two potential Smad binding elements ( SBE ' s ) in the TGFbeta ( 1 ) promoter , supershift assays suggest that at least one of these does not bind Smad4 , and the other is unable to bi 17 good bad
Smad4 Smad1 bind1 Here we show that Smad1 binds to this motif upon BMP stimulation in the presence of the common Smad , Smad4 . 17 good bad
Smad4 Smad3 complex2 Although Smad3 and Smad4 were not detectable in TGFbeta ( 3 ) -inducible AP-1 complexes at the TGFbeta ( 1 ) promoter , stable expression of dominant-negative Smad3 could significantly inhibit the abi 17 good bad
Smad4 D1 associate2 As aberrations in cell cycle regulatory genes are associated with the progression of precursor pancreatic ductal lesions to invasive adenocarcinoma , we examined expression of key cell cycle regulator 16 good bad
Smad4 Smad2 associate1 These results indicate that receptor-dependent phosphorylation of Smad2 on serines 465 and 467 is required in mammalian cells to permit association with Smad4 and to propagate TGF-beta signals . 16 good bad
Smad4 Smad2 associate1 These results indicate that receptor-dependent phosphorylation of Smad2 on serines 465 and 467 is required in mammalian cells to permit association with Smad4 and to propagate TGF-beta signals . 16 good bad
Smad4 Smad2 interact1 Phosphorylation at both sites is required to mediate association of Smad2 with Smad4 in mammalian cells , while in yeast , Smad2 interacts directly with Smad4 and does not require phosphorylation . 16 good bad
Smad4 Smad3 associate1 Activin stimulation triggered association of Dok-1 with Smad3 , as well as association of Smad3 with Smad4 . 16 good bad
Smad4 Smads associate2 This phosphorylation induces association between these receptor-regulated Smads and Smad4 followed by translocation of the heteromeric complex to the nucleus . 16 good bad
Smad4 Smads associate2 This phosphorylation induces association between these receptor-regulated Smads and Smad4 followed by translocation of the heteromeric complex to the nucleus . 15 good bad
Smad4 MAD complex3 MEDEA is most similar to mammalian Smad4 and forms heteromeric complexes with MAD . 14 good bad
Smad4 p38 associate1 Our findings demonstrate that ( i ) decrease of Smad4 mRNA expression is closely associated with defective TGF-beta response and lack of growth inhibition , ( ii ) activation of PAI-1 by TGF-beta may 14 good bad
Smad4 Smad1 bind1 Here we show that Smad1 binds to this motif upon BMP stimulation in the presence of the common Smad , Smad4 . 14 good bad
Smad4 Dpp complex1 Mad forms a heteromeric complex with Drosophila Smad4 ( Medea ) upon phosphorylation by Thick veins ( Tkv ) , a type I receptor for Dpp . 13 good bad
Smad4 activin interact1 After TGF-beta-mediated phosphorylation and association with Smad4 , Smad2 moves to the nucleus and activates expression of specific genes through cooperative interactions with DNA-binding proteins , 12 good bad
Smad4 Smad complex3 Smad proteins activated by TGF-beta form complexes with Smad4 . 12 good bad
Smad4 p16 associate3 Aberrant p16 ( INK4A ) and DPC4 Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma . 11 good bad
Smad4 Delta associate1 c-Fos , FosB Delta FosB , and JunB were associated with Smad4 . 10 good bad
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Text2Knowledge ... Yong Huang 2002