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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
p21 D1 associate1 Cyclin D1 overexpression was found in 12 cases ( 50 % ) , it was often associated with p21 expression ( chi2 = 10 . 13 good bad
p21 ERK1 bind3 Western blot and immunoprecipitation techniques were used to analyze expression of cell-cycle proteins ( cyclin A , cyclin E , p53 , and p21 ) , signaling-related proteins ( ErbB1 , ErbB2 , and Raf-1 10 good bad
p21 PCNA associate2 bFGF-induced cell death was associated with up-regulation of p21 and p53 , down-regulation of PCNA and cyclin A and a decrease in active pRb1 , changes consistent with accumulation of cells in G1 . 9 good bad
p21 PCNA bind1 A p21 mutant that lacked the ability to bind proliferating cell nuclear antigen ( PCNA ) retained the ability to induce both ROS and permanent growth arrest . 9 good bad
p21 ERK1 bind3 Western blot and immunoprecipitation techniques were used to analyze expression of cell-cycle proteins ( cyclin A , cyclin E , p53 , and p21 ) , signaling-related proteins ( ErbB1 , ErbB2 , and Raf-1 8 good bad
p21 D1 associate1 Cyclin D1 overexpression was found in 12 cases ( 50 % ) , it was often associated with p21 expression ( chi2 = 10 . 7 good bad
p21 Grap2 interact2 Associated with the acceleration of cell growth , expression of p53 , p21 and GCIP ( Grap2 cyclin-D interacting protein ) is downregulated in the hTERT-transfected cells . 7 good bad
p21 p27 associate2 Further , apigenin treatment of LNCaP cells resulted in G1 arrest in cell cycle progression which was associated with a marked decrease in the protein expression of cyclin D1 , D2 and E and their acti 7 good bad
p21 Hsp90 bind1 Western blot and immunoprecipitation techniques were used to analyze expression of cell-cycle proteins ( cyclin A , cyclin E , p53 , and p21 ) , signaling-related proteins ( ErbB1 , ErbB2 , and Raf-1 6 good bad
p21 p16 complex2 METHODS : Expression of HCV antigens ( CP10 , NS3 and NS5 ) and several cancer-associated gene products ( ras p21 , c-myc , c-erbB-2 , mutated p53 and p16 protein ) in the tissues of hepatocellular ca 6 good bad
p21 D1 associate2 CONCLUSION : JTE-522 inhibits cell proliferation and induces apoptosis in RL95-2 cells , which may be associated with the activation of caspase-3-like proteases , down-regulation of the expression of 5 good bad
p21 p16 bind1 All of these findings establish that p21 mediates senescence by a mechanism involving ROS accumulation which does not require either its PCNA binding or the CDK inhibitory functions shared with p16 . 5 good bad
p21 p27 complex1 Cyclin D3 cdk6 activity was readily detectable in quiescent liver and changed little after PH , and this complex appeared to play a minor role in sequestering p21 and p27 . 3 good bad
p21 PCNA associate2 bFGF-induced cell death was associated with up-regulation of p21 and p53 , down-regulation of PCNA and cyclin A and a decrease in active pRb1 , changes consistent with accumulation of cells in G1 . 2 good bad
p21 Telomerase associate1 Telomerase activity in microdissected human breast cancer tissues : association with p53 , p21 and outcome . 2 good bad
p21 CYP1A1 bind1 Treatment of sensitive human MCF7 cells with AF resulted in increased CYP1A1 mRNA and CYP1A1 1A2 protein followed by covalent binding of an AF metabolite to DNA , phosphorylation and stabilization of -1 good bad
p21 p27 complex1 Cyclin D1 formed complexes primarily with cyclin-dependent kinase 4 ( cdk4 ) , which were markedly activated in the regenerating liver and readily sequestered the cell cycle inhibitory proteins , p21 -1 good bad
p21 G2 associate1 Upon release of these cells from drug-medium , p21 ( waf1 ) gradually returned to control levels , which was associated with an easing of the block at G2 M and an induction of apoptosis . -5 good bad
p21 D1 associate1 Cyclin D1 overexpression was found in 12 cases ( 50 % ) , it was often associated with p21 expression ( chi2 = 10 . -7 good bad
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Text2Knowledge ... Yong Huang 2002