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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
p38 AKT complex1 The signalling pathways regulating apoptosis are complex and involve kinases such as MAPK , JNK , p38 and AKT . 245 good bad
p38 RIP associate1 We also demonstrate that the RIP noncatalytic intermediate domain associates in vivo with an endogenous MAPKKK that can activate the p38 pathway in vitro . 168 good bad
p38 ERK associate2 Stable overexpression of murine leukocyte-type 12 15-lipoxygenase in VSMCs increased the levels of cell-associated 12 ( S ) -HETE as well as basal activity of both ERK and p38 MAPKs . 167 good bad
p38 JNK complex1 Exposure of cells to either proliferative or stressful stimuli elicits a complex response involving one or more distinct phosphorylation cascades culminating in the activation of multiple members of t 161 good bad
p38 MAP complex1 Lastly , immune complex protein kinase assays , using [ gamma-32P ] ATP and activating transcription factor 2 ( ATF2 ) as substrates , showed increased p38 MAP kinase activity from LPS-stimulated huma 150 good bad
p38 JNK bind1 We identified the stress-activated protein kinase kinase 1 as an upstream activator of p38 JNK , and we demonstrated that activation of AP-1 binding proceeded p38 JNK stimulation . 143 good bad
p38 Cdc42 bind1 Cdc42 and the related small GTP binding protein Rac1 can activate the SAPK JNK and p38 RK stress-responsive kinase cascades , suggesting that MLK-3 may have a role in upstream regulation of these pa 139 good bad
p38 JNK associate2 The association of cells with fibronectin fibrils has been shown to regulate the JNK and p38 signaling pathways . 138 good bad
p38 Tiam1 interact3 Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade . 137 good bad
p38 TRAF2 interact1 Germinal center kinase couples TRAF2 to mitogen-activated protein kinase ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kina 129 good bad
p38 JNK associate2 IR-induced apoptosis is associated with activation of SAPK JNK and p38 kinase , in contrast to Dex-induced apoptosis , which is not associated with activation of stress kinases . 113 good bad
p38 JNK bind2 Furthermore , the binding between LMW-DSP2 and p38 and SAPK JNK was also not disrupted by such mutations . 113 good bad
p38 Grb2 bind1 Whereas enhanced Grb2 binding increased the phosphorylation of the mitogen-activated protein kinase extracellular signal-regulated protein kinases ( MAPK ERK ) and abrogated that of p38 MAPK , PI3K 110 good bad
p38 12 bind1 The use of the specific inhibitors of ERK-1 ERK-2 ( PD 98059 ) and p38 SAPK-2 ( SB 203580 ) phosphorylation also indicates the role of MAPKs , with possible involvement of cAMP response element bind 109 good bad
p38 GADD153 bind1 Activated p38 phosphorylates transcription factors important in the regulation of cell growth and apoptosis , including activating transcription factor 2 ( ATF2 ) , Max , cAMP response element-binding 93 good bad
p38 cadherin associate1 p38 MAP kinase activation appears to be an important upstream signaling event associated with increased endothelial permeability and vascular endothelial cadherin redistribution . 82 good bad
p38 amyloid associate1 Activation of c-Jun N-terminal kinase and p38 in an Alzheimer ' s disease model is associated with amyloid deposition . 75 good bad
p38 JNK associate2 The association of cells with fibronectin fibrils has been shown to regulate the JNK and p38 signaling pathways . 75 good bad
p38 JNK associate3 We show that JNK , ERK , and p38 physically associate with the NFATc N-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating NFATc subcellula 72 good bad
p38 CSBP complex1 Exposure of cells to either proliferative or stressful stimuli elicits a complex response involving one or more distinct phosphorylation cascades culminating in the activation of multiple members of t 67 good bad
p38 ERK interact2 Kinase assays indicated that ATA inhibited IkappaB kinase ( IKK ) , extracellular signal-regulated kinase ( ERK ) , and p38 mitogen-activated protein kinase ( MAPK ) activity both in vivo and in vitro 52 good bad
p38 IB2 bind1 IB2 JIP2 is a scaffold for the p38 mitogen-activated protein ( MAP ) kinase cascade because it binds to the Rac target MLK3 , the MAP kinase kinase MKK3 , and the p38 MAP kinase . 51 good bad
p38 Tiam1 interact3 Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade . 49 good bad
p38 ATF2 bind1 The AP-1 complex contained phosphorylated c-Jun and ATF2 and its DNA binding activity was blocked by the p38 MAPK inhibitor SB203580 . 37 good bad
p38 Tiam1 interact3 Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade . 36 good bad
p38 MEK1 associate3 Experiments with transfected cells that expressed constitutively activated MEK1 and a specific inhibitor of p38 also suggested that inactivation of ERKs and activation of p38 might be associated with 35 good bad
p38 GADD153 bind1 Activated p38 phosphorylates transcription factors important in the regulation of cell growth and apoptosis , including activating transcription factor 2 ( ATF2 ) , Max , cAMP response element-binding 27 good bad
p38 TRAF2 interact1 Germinal center kinase couples TRAF2 to mitogen-activated protein kinase ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kina 24 good bad
p38 MKP-5 bind1 MKP-5 and CL100 MKP-1 also bind to p38 alpha and -beta , but not gamma or delta . 20 good bad
p38 ATF2 complex1 Lastly , immune complex protein kinase assays , using [ gamma-32P ] ATP and activating transcription factor 2 ( ATF2 ) as substrates , showed increased p38 MAP kinase activity from LPS-stimulated huma 15 good bad
p38 PKB bind1 Interestingly , using various pathway inhibitors , it appears that the phosphatidylinositol 3-kinase PKB and PKC pathways elevate IL-6 mRNA synthesis , at least in part , by enhancing the phosphoryla 11 good bad
p38 JNK bind2 Binding of IL-3 IL-5 GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways , including the Ras-Raf-ERK , the JAK STAT , the phosphatidylinosi 9 good bad
p38 JNK complex1 Immunecomplex kinase assays showed that ERK and JNK were significantly activated in the liver extract from fasted rats whereas p38 kinase showed no activation . 6 good bad
p38 STAT3 bind2 Plasmin-induced DNA binding of STAT1 and STAT3 was blocked by SB203580 and AG490 , inhibitors of p38 MAPK and JAK , respectively , but not by U0126 , an inhibitor of MKK1 2 . 5 good bad
p38 Cdc42 bind1 Cdc42 and the related small GTP binding protein Rac1 can activate the SAPK JNK and p38 RK stress-responsive kinase cascades , suggesting that MLK-3 may have a role in upstream regulation of these pa 3 good bad
p38 Tiam1 interact3 Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade . -7 good bad
p38 JNK associate2 IR-induced apoptosis is associated with activation of SAPK JNK and p38 kinase , in contrast to Dex-induced apoptosis , which is not associated with activation of stress kinases . -13 good bad
p38 p42 bind2 Binding of chemokines to their receptors on leukocytes leads to the activation of heterotrimeric G proteins that initiate multiple signaling cascades , including p38 and p42 p44 mitogen-activated pro -14 good bad
p38 JNK complex2 Wortmannin-mediated activation of the SAPK JNK and p38 MAPK pathways also resulted in the mobilization of activator protein-1 complex to the nuclear compartment . -15 good bad
p38 JNK1 complex2 We also show that p38 and JNK1 activated by their upstream kinases induce egr-1 promoter activity through activation of the ternary complex factor , Elk-1 . -16 good bad
p38 EBP bind2 IL-1beta induces DNA binding of both nuclear factor kappaB ( NF-kappaB ) and CAATT-enhancer binding protein ( C EBP ) , and activation of p38 mitogen-activated protein kinase in both subpopulations . -17 good bad
p38 LPS associate1 LPS tolerance in murine macrophages appears to be associated with specific , PMA-reversible defects in MAPK and p38 kinase activation . -18 good bad
p38 JNK bind2 Binding of IL-3 IL-5 GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways , including the Ras-Raf-ERK , the JAK STAT , the phosphatidylinosi -19 good bad
p38 Erk associate3 However , while pretreatment of U937 cells with the kinase inhibitors PD98059 and SB203580 abrogated the osmotic activation of Erk and p38 MAPK , respectively , it did not prevent the associated stimu -25 good bad
p38 Tiam1 bind1 In addition , Tiam1 or Ras-GRF1 binding to IB2 JIP2 increases the association of the components of the p38 MAP kinase signaling cassette with IB2 JIP2 in cells and activates scaffold-associated p38 -26 good bad
p38 Gas6 associate1 On the contrary we found that the late constitutive increase of p38 MAPK activity associated with cell death was downregulated in Gas6-treated NIH3T3 cells thus suggesting that Gas6 might promote surv -32 good bad
p38 EBP bind2 IL-1beta induces DNA binding of both nuclear factor kappaB ( NF-kappaB ) and CAATT-enhancer binding protein ( C EBP ) , and activation of p38 mitogen-activated protein kinase in both subpopulations . -33 good bad
p38 RIP associate1 We also demonstrate that the RIP noncatalytic intermediate domain associates in vivo with an endogenous MAPKKK that can activate the p38 pathway in vitro . -34 good bad
p38 MKK3 associate1 Interestingly overexpression of wild type MKK3 6 was associated with phosphorylation of p38 ( MAPK ) ; however , in the absence of IL-1beta , iNOS expression was not enhanced . -35 good bad
p38 Erk1 bind2 Insulin-like Growth Factor-binding Protein-5 ( IGFBP-5 ) Stimulates Growth and IGF-I Secretion in Human Intestinal Smooth Muscle by Ras-dependent Activation of p38 MAP Kinase and Erk1 2 Pathways . -37 good bad
p38 MKP-3 interact1 We now show that MKP-3 enzymatic specificity is paralleled by tight binding to both ERK1 and ERK2 while , in contrast , little or no interaction with either c-Jun N-terminal kinase stress activated p -37 good bad
p38 IB2 bind1 IB2 JIP2 is a scaffold for the p38 mitogen-activated protein ( MAP ) kinase cascade because it binds to the Rac target MLK3 , the MAP kinase kinase MKK3 , and the p38 MAP kinase . -45 good bad
p38 TYK2 complex2 Here we demonstrate the ability to simultaneously detect activated kinase members of the mitogen-activated protein kinases family ( p38 MAPK , p44 42 MAPK , JNK SAPK ) , members of cell survival pat -46 good bad
p38 MEK1 associate3 Experiments with transfected cells that expressed constitutively activated MEK1 and a specific inhibitor of p38 also suggested that inactivation of ERKs and activation of p38 might be associated with -55 good bad
p38 CCR5 associate1 CONCLUSIONS : We conclude that the phosphorylation of p38 MAPK associated with the activation of NF-kappaB may be involved in the upregulation of intrarenal MIP-1alpha and the utilization of CCR5 sign -57 good bad
p38 JNK1 complex2 We also show that p38 and JNK1 activated by their upstream kinases induce egr-1 promoter activity through activation of the ternary complex factor , Elk-1 . -59 good bad
p38 JNK complex1 Immunecomplex kinase assays showed that ERK and JNK were significantly activated in the liver extract from fasted rats whereas p38 kinase showed no activation . -66 good bad
p38 MAPK associate1 Mitogen-activated protein kinase ( MAPK ) signaling cascades trigger stimulus-specific responses in cells with ERK being associated with proliferation and differentiation , and JNK SAPK and p38 media -66 good bad
p38 EBP bind1 Transfection with dominant negative ( dn ) forms of CREB and C EBP , the two CRE-binding transcription factors targeted by the p38 MAPK pathway , resulted in opposite effects i . -68 good bad
p38 Tiam1 bind1 In addition , Tiam1 or Ras-GRF1 binding to IB2 JIP2 increases the association of the components of the p38 MAP kinase signaling cassette with IB2 JIP2 in cells and activates scaffold-associated p38 -72 good bad
p38 Gas6 associate1 On the contrary we found that the late constitutive increase of p38 MAPK activity associated with cell death was downregulated in Gas6-treated NIH3T3 cells thus suggesting that Gas6 might promote surv -77 good bad
p38 CCR5 associate1 CONCLUSIONS : We conclude that the phosphorylation of p38 MAPK associated with the activation of NF-kappaB may be involved in the upregulation of intrarenal MIP-1alpha and the utilization of CCR5 sign -78 good bad
p38 JNK complex1 The inhibitory effect of p38 ( mapk ) appears more complex and may be due to the ability of p38 ( mapk ) to inhibit LPS-induced JNK activation . -78 good bad
p38 cadherin associate1 p38 MAP kinase activation appears to be an important upstream signaling event associated with increased endothelial permeability and vascular endothelial cadherin redistribution . -89 good bad
p38 ERK complex2 The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light . -93 good bad
p38 Smad4 associate1 Our findings demonstrate that ( i ) decrease of Smad4 mRNA expression is closely associated with defective TGF-beta response and lack of growth inhibition , ( ii ) activation of PAI-1 by TGF-beta may -113 good bad
p38 ERK associate1 Mitogen-activated protein kinase ( MAPK ) signaling cascades trigger stimulus-specific responses in cells with ERK being associated with proliferation and differentiation , and JNK SAPK and p38 media -115 good bad
p38 Tiam1 bind1 In addition , Tiam1 or Ras-GRF1 binding to IB2 JIP2 increases the association of the components of the p38 MAP kinase signaling cassette with IB2 JIP2 in cells and activates scaffold-associated p38 -122 good bad
p38 TYK2 complex2 Here we demonstrate the ability to simultaneously detect activated kinase members of the mitogen-activated protein kinases family ( p38 MAPK , p44 42 MAPK , JNK SAPK ) , members of cell survival pat -146 good bad
p38 MIP bind1 Macrophage inflammatory protein 1 beta ( MIP 1 beta ) binding to its cognate receptor CCR5 resulted in activation of the related adhesion focal tyrosine kinase ( RAFTK ) , with subsequent activation o -147 good bad
p38 Tiam1 bind1 In addition , Tiam1 or Ras-GRF1 binding to IB2 JIP2 increases the association of the components of the p38 MAP kinase signaling cassette with IB2 JIP2 in cells and activates scaffold-associated p38 -149 good bad
p38 ang bind1 Co-incubation with ang II and high glucose had no additive effect on TGF-beta1 promoter activity , protein binding to the AP-1 box B or activation of p38 MAPK . -173 good bad
p38 JNK bind1 We identified the stress-activated protein kinase kinase 1 as an upstream activator of p38 JNK , and we demonstrated that activation of AP-1 binding proceeded p38 JNK stimulation . -192 good bad
p38 Smad4 associate1 Our findings demonstrate that ( i ) decrease of Smad4 mRNA expression is closely associated with defective TGF-beta response and lack of growth inhibition , ( ii ) activation of PAI-1 by TGF-beta may -192 good bad
p38 JNK bind2 Furthermore , the binding between LMW-DSP2 and p38 and SAPK JNK was also not disrupted by such mutations . -196 good bad
p38 ERK associate2 Stable overexpression of murine leukocyte-type 12 15-lipoxygenase in VSMCs increased the levels of cell-associated 12 ( S ) -HETE as well as basal activity of both ERK and p38 MAPKs . -209 good bad
p38 MKP-5 bind1 MKP-5 and CL100 MKP-1 also bind to p38 alpha and -beta , but not gamma or delta . -217 good bad
p38 JNK associate3 We show that JNK , ERK , and p38 physically associate with the NFATc N-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating NFATc subcellula -227 good bad
p38 JNK complex2 The recent discovery of two other MAPK subtypes , the JNK SAPK subfamily and p38 RK ( mammalian equivalents of HOG1 in yeast ) , reveals extreme complexity within the family and , most intriguingly -235 good bad
p38 JNK complex1 The signalling pathways regulating apoptosis are complex and involve kinases such as MAPK , JNK , p38 and AKT . -260 good bad
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Text2Knowledge ... Yong Huang 2002