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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
TP53 BRCA2 associate2 The great majority of breast cancer cases are not associated with a mutated gene of high penetrance such as BRCA1 , BRCA2 and TP53 . 29 good bad
TP53 BRCA2 associate1 By combining several such studies , we show in this study that somatic TP53 abnormalities are more common in breast cancer associated with BRCA1 or BRCA2 germ-line mutations than in sporadic breast ca 10 good bad
TP53 P53 associate1 The TP53 status of the primary tumor was predictive for the status of the recurrent tumor , and tumor recurrence progression was associated with an increase of P53 immunopositive cells in 68 % of the 0 good bad
TP53 BRCA1 associate1 Recent work has shown that breast cancers occurring in women carrying germ-line BRCA1 mutations tend to have clinicopathological features that are usually associated with a poor prognosis , such as hi -1 good bad
TP53 BRCA1 associate3 CONCLUSIONS : Our findings provide novel evidence that loss of BRCA1 function in human cells activates the p53 DNA damage response pathway and that loss of this pathway , by somatic mutation of TP53 , -2 good bad
TP53 BRCA1 associate3 A worse clinical outcome in early-onset LOH related cancers emerged from follow-up data : TP53 and BRCA1 LOH were associated with a shorter relapse free interval ( RFI ) ( p = 0 . -15 good bad
TP53 BRCA1 associate1 Recent work has shown that breast cancers occurring in women carrying germ-line BRCA1 mutations tend to have clinicopathological features that are usually associated with a poor prognosis , such as hi -19 good bad
TP53 BRCA2 associate1 TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations : distinctive spectrum and structural distribution . -20 good bad
TP53 PTEN associate3 Conversely , alterations in the PTEN and TP53 genes seem to define distinct subgroups of endometrial carcinoma , the former associated with diploidy and MSI , the latter with macroscopic chromosomal i -26 good bad
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Text2Knowledge ... Yong Huang 2002