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Gene 1 | Gene 2 | Interaction Type | Sentence | Value | Judge me |
TP53 | BRCA2 | associate2 | The great majority of breast cancer cases are not associated with a mutated gene of high penetrance such as BRCA1 , BRCA2 and TP53 . | 29 | good bad |
TP53 | BRCA2 | associate1 | By combining several such studies , we show in this study that somatic TP53 abnormalities are more common in breast cancer associated with BRCA1 or BRCA2 germ-line mutations than in sporadic breast ca | 10 | good bad |
TP53 | P53 | associate1 | The TP53 status of the primary tumor was predictive for the status of the recurrent tumor , and tumor recurrence progression was associated with an increase of P53 immunopositive cells in 68 % of the | 0 | good bad |
TP53 | BRCA1 | associate1 | Recent work has shown that breast cancers occurring in women carrying germ-line BRCA1 mutations tend to have clinicopathological features that are usually associated with a poor prognosis , such as hi | -1 | good bad |
TP53 | BRCA1 | associate3 | CONCLUSIONS : Our findings provide novel evidence that loss of BRCA1 function in human cells activates the p53 DNA damage response pathway and that loss of this pathway , by somatic mutation of TP53 , | -2 | good bad |
TP53 | BRCA1 | associate3 | A worse clinical outcome in early-onset LOH related cancers emerged from follow-up data : TP53 and BRCA1 LOH were associated with a shorter relapse free interval ( RFI ) ( p = 0 . | -15 | good bad |
TP53 | BRCA1 | associate1 | Recent work has shown that breast cancers occurring in women carrying germ-line BRCA1 mutations tend to have clinicopathological features that are usually associated with a poor prognosis , such as hi | -19 | good bad |
TP53 | BRCA2 | associate1 | TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations : distinctive spectrum and structural distribution . | -20 | good bad |
TP53 | PTEN | associate3 | Conversely , alterations in the PTEN and TP53 genes seem to define distinct subgroups of endometrial carcinoma , the former associated with diploidy and MSI , the latter with macroscopic chromosomal i | -26 | good bad |
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Text2Knowledge ... Yong Huang
2002
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