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Gene 1 | Gene 2 | Interaction Type | Sentence | Value | Judge me |
Wnt | Axin | bind1 | In attempting to clarify the roles of Dvl in the Wnt signaling pathway , we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax ( for inhibition of the Dvl and Axin compl | 7 | good bad |
Wnt | Axin | bind1 | In attempting to clarify the roles of Dvl in the Wnt signaling pathway , we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax ( for inhibition of the Dvl and Axin compl | 7 | good bad |
Wnt | Axin | complex1 | PP2C exists in a complex with Dvl , beta-catenin , and Axin , a negative regulator of Wnt signaling . | 6 | good bad |
wnt | dishevelled | interact3 | Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction . | 6 | good bad |
Wnt | Axin | complex1 | PP2C exists in a complex with Dvl , beta-catenin , and Axin , a negative regulator of Wnt signaling . | 5 | good bad |
Wnt | Axin | interact1 | Other components of the Wnt signalling pathway , including Dvl , glycogen synthase kinase-3beta , beta-catenin , and adenomatous polyposis coli , interact with Axin , and the phosphorylation and stabi | 5 | good bad |
Wnt | catenin | complex2 | Wnt signals interfere with beta-catenin turnover , resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors . | 5 | good bad |
Wnt | PP2A | bind1 | Different subunits of PP2A bind to Axin and Adenomatous Polyposis Coli , components of the Wnt signal transduction pathway . | 5 | good bad |
Wnt | PP2A | bind1 | Different subunits of PP2A bind to Axin and Adenomatous Polyposis Coli , components of the Wnt signal transduction pathway . | 5 | good bad |
Wnt | Axin | interact1 | Other components of the Wnt signaling pathway , including Dvl , glycogen synthase kinase-3beta ( GSK-3beta ) , beta-catenin , and adenomatous polyposis coli ( APC ) , interact with Axin , and the phos | 4 | good bad |
Wnt | Axin | interact1 | Other components of the Wnt signalling pathway , including Dvl , glycogen synthase kinase-3beta , beta-catenin , and adenomatous polyposis coli , interact with Axin , and the phosphorylation and stabi | 4 | good bad |
Wnt | Dishevelled | interact2 | Our results indicate that different Wnt Fz signals activate distinct intracellular pathways , and Dishevelled discriminates among them by distinct domain interactions . | 4 | good bad |
Wnt | Akt | associate1 | Therefore , Akt acts in association with Dvl as an important regulator of the Wnt signaling pathway . | 3 | good bad |
Wnt | Axin | complex1 | CKIepsilon forms a complex with Axin and the other downstream components of the Wnt pathway . | 3 | good bad |
Wnt | Axin | complex1 | CKIepsilon forms a complex with Axin and the other downstream components of the Wnt pathway . | 3 | good bad |
Wnt | Dishevelled | interact2 | Our results indicate that different Wnt Fz signals activate distinct intracellular pathways , and Dishevelled discriminates among them by distinct domain interactions . | 3 | good bad |
wnt | dishevelled | interact3 | Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction . | 3 | good bad |
Wnt | integrin | bind2 | The integrin-dependent binding of deep cells to fibronectin is sufficient to drive membrane localization of Dishevelled-GFP , suggesting that a convergence of integrin and Wnt signaling pathways acts | 3 | good bad |
Wnt | catenin | complex2 | Wnt signals interfere with beta-catenin turnover , resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors . | 2 | good bad |
Wnt | Tcf | interact1 | Upon binding of a Wnt to its receptor , GSK3beta is inhibited through an unknown mechanism involving Dishevelled ( Dsh ) , resulting in the dephosphorylation and stabilization of beta-catenin , which | 2 | good bad |
Wnt | Tcf | interact1 | Upon binding of a Wnt to its receptor , GSK3beta is inhibited through an unknown mechanism involving Dishevelled ( Dsh ) , resulting in the dephosphorylation and stabilization of beta-catenin , which | 2 | good bad |
Wnt | Axin | interact1 | Other components of the Wnt signaling pathway , including Dvl , glycogen synthase kinase-3beta ( GSK-3beta ) , beta-catenin , and adenomatous polyposis coli ( APC ) , interact with Axin , and the phos | 1 | good bad |
Wnt | catenin | complex2 | Wnt signal transduction is controlled by the rate of degradation of beta-catenin by a complex of proteins including glycogen synthase kinase 3 ( GSK3 ) , adenomatous polyposis coli , and Axin . | 1 | good bad |
Wnt | catenin | interact1 | These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin . | 1 | good bad |
WNT | decapentaplegic | interact1 | Moreover the wingless WNT pathway displays antagonistic interactions with the DPP ( decapentaplegic ) pathway , which regulates branching along the dorsoventral axis . | 0 | good bad |
Wnt | catenin | interact1 | These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin . | -3 | good bad |
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Text2Knowledge ... Yong Huang
2002
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