AXL

Cell Cycle

• Activation of the Axl receptor tyrosine kinase induces mitogenesis and transformation in 32D cells McCloskey P, Pierce J, Koski RA, Varnum B, Liu ET

Clinical

• Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia   Rochlitz C, Lohri A, Bacchi M, Schmidt M, Nagel S, Fopp M, Fey MF, Herrmann R, Neubauer A.

Function

• Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines  Dirks W, Rome D, Ringel F, Jager K, MacLeod RA, Drexler HG.

• Differential expression of the ufo/axl oncogene in human leukemia-lymphoma cell lines  Challier C, Uphoff CC, Janssen JW, Drexler HG.

• Activation of the Axl receptor tyrosine kinase induces mitogenesis and transformation in 32D cells McCloskey P, Pierce J, Koski RA, Varnum B, Liu ET

• Identification of a novel receptor tyrosine kinase expressed in acute myeloid leukemic blasts  Crosier PS, Hall LR, Vitas MR, Lewis PM, Crosier KE.

Phenotype

• Noninsulin-dependent diabetes mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor  Augustine KA, Rossi RM, Van G, Housman J, Stark K, Danilenko D, Varnum B, Medlock E.

• Activation of the Axl receptor tyrosine kinase induces mitogenesis and transformation in 32D cells McCloskey P, Pierce J, Koski RA, Varnum B, Liu ET.

Tumor Gene Type

• Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia   Rochlitz C, Lohri A, Bacchi M, Schmidt M, Nagel S, Fopp M, Fey MF, Herrmann R, Neubauer A

• Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines  Dirks W, Rome D, Ringel F, Jager K, MacLeod RA, Drexler HG.

• Noninsulin-dependent diabetes mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor  Augustine KA, Rossi RM, Van G, Housman J, Stark K, Danilenko D, Varnum B, Medlock E.

• Expression of axl a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis Neubauer A, Fiebeler A, Graham DK, O'Bryan JP, Schmidt CA, Barckow P, Serke S, Siegert W, Snodgrass HR, Huhn D, et al.

• Axl a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase  O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET.