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BAX
| OMIM | GENE CARDS | CGAP |
| 600040 | BAX | 159428 |
| SYNONYMS | BCL2-associated X protein |
| Protein Sequence |
Cell Type Distribution
Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis Loro LL. Vintermyr OK. Liavaag PG. Jonsson R. Johannessen AC. Hum Pathol 30: 1097-1105 (1999)
Clinical
Dysregulated expression of bcl-2 and bax in oral carcinomas Chen Y. Kayano T. Takagi M. J Oral Pathol Med 29: 63-69 (2000)
The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue Xie X. Clausen OP. De Angelis P. Boysen M. Cancer 86: 913-920 (1999)
Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis Loro LL. Vintermyr OK. Liavaag PG. Jonsson R. Johannessen AC. Hum Pathol 3: 1097-1105 (01999)
Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis Sakakura C. Sweeney EA. Shirahama T. Igarashi Y. Hakomori S. Nakatani H. Tsujimoto H. Imanishi T. Ohgaki M. Ohyama T. Yamazaki J. Hagiwara A. Yamaguchi T. Sawai K. Takahashi T. Int J Cancer 67: 101-105 (1996)
Complementation
Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis Nishimura A. J Dent Res 78: 1264-1269 (1999)
Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma Fujieda S. Inuzuka M. Tanaka N. Sunaga H. Fan GK. Ito T. Sugimoto C. Tsuzuki H. Saito H. Int J Cancer 84: 315-320 (1999)
Function
Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer Bargou RC. Wagener C. Bommert K. Mapara MY. Daniel PT. Arnold W. Dietel M. Guski H. Feller A. Royer HD. Dorken B. J Clin Invest 97: 2651-2659 (1996)
Gene Frequency Tumor
Apoptosis-associated proteins and the development of oral squamous cell carcinoma Schoelch ML. Le QT. Silverman S Jr. McMillan A. Dekker NP. Fu KK. Ziober BL. Regezi JA. Oral Oncol 35: 77-85 (1999)
Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity Jordan RC. Catzavelos GC. Barrett AW. Speight PM. Eur J Cancer B Oral Oncol 32B: 394-400 (1996)
Regulation
Effect of 9-cis-retinoic acid on oral squamous cell carcinoma cell lines Hayashi K. Yokozaki H. Naka K. Yasui W. Yajin K. Lotan R. Tahara E. Cancer Lett 151: 199-208 (2000)
Dysregulated expression of bcl-2 and bax in oral carcinomas Chen Y. Kayano T. Takagi M. J Oral Pathol Med 29: 63-69 (2000)
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