IRF1

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IRF1

OMIM	GENE CARDS	CGAP
147575	IRF1	80645

SYNONYMS	interferon regulatory factor 1
	IRF-1

Cell Cycle

Stat3 is a critical transcription factor causing expression of junB and IRF1 Narimatsu M, Nakajima K, Ichiba M, Hirano T.

Cell Type Distribution

Gene expression in white blood cells in chronic myeloid leukemia Bruchova H, Klamova H, Brdicka R.

Chromosome Human

IRF1 maps outside the commonly deleted segment of the 5q chromosome and that loss of IRF1 is not solely responsible for the development of the 5q syndrome Boultwood J, Fidler C, Lewis S, MacCarthy A, Sheridan H, Kelly S, Oscier D, Buckle VJ, Wainscoat JS.

Clinical

Expression of interferon regulatory factor (IRF) genes and response to interferon-alpha in chronic myeloid leukaemia Hochhaus A, Yan XH, Willer A, Hehlmann R, Gordon MY, Goldman JM, Melo JV.

Development

Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors Nakanishi M, Tanaka K, Takahashi T, Kyo T, Dohy H, Fujiwara M, Kamada N.

IRF1 maps outside the commonly deleted segment of the 5q chromosome and that loss of IRF1 is not solely responsible for the development of the 5q syndrome Boultwood J, Fidler C, Lewis S, MacCarthy A, Sheridan H, Kelly S, Oscier D, Buckle VJ, Wainscoat JS.

DNA Binding

The human RIL gene: mapping to human chromosome 5q31.1 Bashirova AA, Markelov ML, Shlykova TV, Levshenkova EV, Alibaeva RA, Frolova EI.

High ratio of IRF1/IRF2 expression may be associated with good cytogenetic and molecular response to IFN-alpha in CML Hochhaus A, Yan XH, Willer A, Hehlmann R, Gordon MY, Goldman JM, Melo JV.

Two interferon (IFN) alpha-regulated genes, IRF1/ISGF2 and PKR/p68 kinase, may function as tumor suppressor genes Colamonici OR, Porterfield B, Domanski P, Handa RK, Flex S, Samuel CE, Pine R, Diaz MO.

Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia Boultwood J, Fidler C, Lewis S, MacCarthy A, Sheridan H, Kelly S, Oscier D, Buckle VJ, Wainscoat JS.

Function

Gene expression in white blood cells in chronic myeloid leukemia Bruchova H, Klamova H, Brdicka R.

Ligand Binding

Ligand-independent anti-oncogenic activity of the alpha subunit of IRF1 Colamonici OR, Porterfield B, Domanski P, Handa RK, Flex S, Samuel CE, Pine R, Diaz MO.

Regulation

Gene expression in white blood cells in chronic myeloid leukemia Bruchova H, Klamova H, Brdicka R.

Tumor Type

Ligand-independent anti-oncogenic activity of the alpha subunit of IRF1. Colamonici OR, Porterfield B, Domanski P, Handa RK, Flex S, Samuel CE, Pine R, Diaz MO.

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