LAF4

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LAF4

OMIM	GENE CARDS	CGAP
601464	LAF4	38070

SYNONYMS	MLLT2
	lymphoid nuclear protein 4

Chromosome Human

The AF5q31 protein was homologous to AF4-related proteins, including AF4, LAF4, and FMR2 Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y.

Clinical

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y.

DNA binding

EAF1 contains a limited region of homology with the transcriptional activation domains of three other genes fused to MLL in leukemias, AF4, LAF4, and AF5q31 Luo RT, Lavau C, Du C, Simone F, Polak PE, Kawamata S, Thirman MJ.

AF5q31 and AF4 might define a new family particularly involved in the pathogenesis of 11q23-associated-ALL. Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y.

DNA Structure

ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Luo RT, Lavau C, Du C, Simone F, Polak PE, Kawamata S, Thirman MJ.

Function

ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Luo RT, Lavau C, Du C, Simone F, Polak PE, Kawamata S, Thirman MJ.

Protein binding

Expression of the MLL-ELL fusion protein may have a dominant effect on the normal protein-protein interactions of ELL. Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ

Tumor type

Critical role for MLL partner genes and their protein-protein interactions in 11q23 leukemogenesis Luo RT, Lavau C, Du C, Simone F, Polak PE, Kawamata S, Thirman MJ.

AF5q31 and AF4 might define a new family particularly involved in the pathogenesis of 11q23-associated-ALL. Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y.

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