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PBX2

                                                    

OMIM  GENE CARDS CGAP  
 176311  PBX2  93728

 

SYNONYMS pre-B-cell leukemia transcription factor 2
HOX12
G17
PBX2MHC

        

Protein Sequence

 

Chromosome Human

  • E2A-PBX1 is a chimeric gene formed by the t(1;19)(q23;p13.3) chromosomal translocation of pediatric pre-B-cell leukemia  Lu Q, Wright DD, Kamps MP.

DNA Binding

  • Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias  LeBrun DP, Cleary ML.

Function

Homologue

Ligand Binding

Protein Binding

Regulation

  • Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias  LeBrun DP, Cleary ML.

Tumor Gene Type

  • Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation  Lu Q, Wright DD, Kamps MP

Tumor Type

  • Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.  LeBrun DP, Cleary ML.

 

 

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