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RUNX1

OMIM	GENE CARDS	CGAP
151385	RUNX1	129914

SYNONYMS	PEBP2A2
	AMLCR1
	AML1
	CBFA2
	runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
	acute myeloid leukemia 1 protein (oncogene AML-1), core-binding factor, alpha subunit
	core-binding factor, runt domain, alpha subunit 2 (acute myeloid leukemia 1; aml1 oncogene)

Chromosome Human

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG.

Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1 Levanon D, Glusman G, Bangsow T, Ben-Asher E, Male DA, Avidan N, Bangsow C, Hattori M, Taylor TD, Taudien S, Blechschmidt K, Shimizu N, Rosenthal A, Sakaki Y, Lancet D, Groner Y.

Fusion genes in leukemia - an emerging network Bohlander SK.

Development

Downregulation of RUNX1 may contribute to E2A-HLF-mediated leukemogenesis Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S, Look AT.

Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development Fujita Y, Nishimura M, Taniwaki M, Abe T, Okuda T.

DNA Binding

CBFB and Runx1 are required for normal hematopoiesis and are also frequent targets of chromosomal translocations in acute leukemias in humans Miller JD, Stacy T, Liu PP, Speck NA.

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp Bravo J, Li Z, Speck NA, Warren AJ.

Crystallization and preliminary studies of the DNA-binding runt domain of AML1 Backstrom S, Huang SH, Wolf-Watz M, Xie XQ, Hard T, Grundstrom T, Sauer UH.

DNA Structure

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain Nagata T, Werner MH.

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp Bravo J, Li Z, Speck NA, Warren AJ.

Function

Alterations in subnuclear trafficking of nuclear regulatory factors in acute leukemia Meyers S, Hiebert SW.

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp Bravo J, Li Z, Speck NA, Warren AJ.

Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development Fujita Y, Nishimura M, Taniwaki M, Abe T, Okuda T.

Oncogenic Activation

Alterations in subnuclear trafficking of nuclear regulatory factors in acute leukemia Meyers S, Hiebert SW.

Oncogenicity

The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1 Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S, Look AT.

Restoring C/EBPalpha expression will have therapeutic implications in RUNX1-CBF2T1-positive leukemias Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG.

Fusion genes in leukemia- an emerging network Bohlander SK.

Protein Binding

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain Nagata T, Werner MH.

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp Bravo J, Li Z, Speck NA, Warren AJ.

Protein Size

Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1 Levanon D, Glusman G, Bangsow T, Ben-Asher E, Male DA, Avidan N, Bangsow C, Hattori M, Taylor TD, Taudien S, Blechschmidt K, Shimizu N, Rosenthal A, Sakaki Y, Lancet D, Groner Y.

Protein Structure

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp Bravo J, Li Z, Speck NA, Warren AJ.

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain Nagata T, Werner MH.

Regulation

Runt domain family of transcription factors play key roles in transcriptional regulation of definitive hematopoiesis and osteogenesis Nagata T, Werner MH.

Restoring C/EBPalpha expression will have therapeutic implications in RUNX1-CBF2T1-positive leukemias Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG.

Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development Fujita Y, Nishimura M, Taniwaki M, Abe T, Okuda T.

Tumor Gene Type

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain Nagata T, Werner MH.

Restoring C/EBPalpha expression will have therapeutic implications in RUNX1-CBF2T1-positive leukemias Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG.

Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development Fujita Y, Nishimura M, Taniwaki M, Abe T, Okuda T.

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y.

Tumor Type

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain Nagata T, Werner MH.

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG.

Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development Fujita Y, Nishimura M, Taniwaki M, Abe T, Okuda T.

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y.

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