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    Latest announcements
    Opportunity: Senior Bioinformatician @ Company in Cambridge, UK
    Submitted by Eugene Mc Daid; posted on Friday, August 18, 2017

    BACKGROUND

    A great position is available with an exciting start-up company based in Cambridge for a senior level Bioinformatician with experience with metagenomics and microbiomes. You would be working with best-in-class microbiological technologies having access to a leading microbiome reference genome database. The client is building a world-leading in-house bioinformatics team to analyse genomes and metagenomes, lead further development databases and establish bespoke analytical pipelines that will be central to biomarker discovery.

    An ideal candidate will have experience in constructing analysis pipelines for the analysis of genomes and/or metagenomes. This is an opportunity for an enthusiastic individual to be involved at the very early stages of this novel area of Live Bacterial Therapeutics.

    RESPONSIBILITIES

    Key Duties:
    • Write production quality software/scripts for organising and analysing sequence data
    • Combine third-party analysis tools, with our own in-house tools, to produce an in-depth annotation pipeline for the annotation of metagenomes and genomes
    • Perform phylogenetic analysis of key marker genes to enable detailed classification of gut microbiome organisms
    • Perform statistical analysis to identify trends within and across datasets
    • Enhance reference database with novel data produced

    REQUIREMENTS

    • PhD in Bioinformatics or related discipline
    • 5 years of experience working with biological analysis tools and databases
    • Demonstrable experience in working in a production bioinformatics environment
    • Experience analysing DNA sequences, ideally genome and/or metagenomes
    • Demonstrable history of producing and executing bioinformatics analysis pipelines
    • Expert knowledge of algorithms/tools in (meta)genome analysis
    • Knowledge of multi-person software development approaches (Agile) and tools (e.g. Git)
    • High level of competency in a scripting language, e.g Python or Perl
    • Experience using R and developing scripts and packages
    • An understanding of how to deliver projects to timescale and budget
    • A natural sense of organisation, team work, as well as sharing knowledge
    • Candidates should be legally entitled to work in the UK

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Bioinformatics, Analyst, Genomics, Metageomics, Drug Discovery, Microbiome, Pipeline, Biomarker, Discovery, DNA, Algorithm, Python, R, Perl, Git, Agile, Cambridge

    BACKGROUND

    Do you want to fight malaria from your computer? Are you a motivated bioinformatician and want to work with the latest sequencing technologies and single cell sequencing?

    The Wellcome Trust Sanger Institute is taking on some of the most difficult challenges in genomic research, to push the boundaries of our understanding of life in ever new and exciting ways. We have an exciting opportunity for you to work within a team of bioinformaticians and biologists to use state-of-the-art genomic and transcriptomic datasets to understand the biology and evolution of malaria parasites.

    In the Parasite Genomics group we produce and analyse DNA sequence data to gain insights into parasite biology and to generate resources of lasting value to the Research community. We use the latest sequence technologies, like Oxford Nanopore, 10X to push the limits of single-cell analysis for parasite genomes.

    We seek to recruit a senior bioinformatician in to our malaria genomics team, to work with DNA and RNA sequencing data. The position would be ideal for an individual to gain valuable experience in using third generation sequencing data, as well as cutting edge single-cell approaches.

    RESPONSIBILITIES

    • Analyse and evaluate 3rd generation sequencing data with existing tools, and with new tools generated in house.
    • Analyse single-cell datasets.
    • Generate programs and pipelines to generate hundreds of high quality malaria-parasite genomes.

    REQUIREMENTS

    • The position will involve both data analysis and programming.
    • Good knowledge of programming, demonstrated by a Masters or PhD degree in Computer Science or Bioinformatics, or PhD in another discipline (such as physics, maths or biology) with a large component of computational work
    • Must have experience in Java, Perl or Python programming and driving projects to completion

    PREFERENCES

    Experience with genome and next generation sequencing analysis or a background in malaria biology.

    TERMS

    Fixed Term Contract for 3 years

    COMPENSATION

    Salary Range: £31,498 to £39,729 plus excellent benefits.

    Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

    ABOUT US

    The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and host Genomics England Limited's 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

    HOW TO APPLY

    Click on the following link: jobs.sanger.ac.uk/wd/p[...]21621

    DEADLINE

    4th September 2017, however applications will be considered and reviewed on an on-going basis.

    POLICY

    Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

    BACKGROUND

    The University of Nebraska-Lincoln (UNL) is hiring a research associate in computational metabolomics as a member of the Center for Biotechnology Bioinformatics Research Core Facility (BCRF) and the Nebraska Research Center for Integrated Biomolecular Communication (CIBC). CIBC is a research center funded by the National Institutes of Health whose projects integrate the research activities of chemists, biochemists, engineers, and bioinformaticians to address critical knowledge gaps in our understanding of how cells communicate and to mechanistically define metabolic and regulatory pathways relevant to disease development and progression. We are establishing state-of-the-art metabolomics and proteomics facilities which apply liquid chromatography-mass spectrometers (LC-MS) and NMR spectrometers to conduct research relevant to CIBC.

    RESPONSIBILITIES

    This individual would focus on the development, implementation and application of computational and analytical approaches for metabolic phenotyping. The primary responsibilities of any successful applicant are to develop and implement data processing pipelines, including the experimental design, pre-processing, and statistical analysis of large scale LC-MS and NMR-based metabolomics studies; collaborate with researchers within and external to the university (academic, industry, scientific instrument manufacturers); and provide training and support in relevant areas of bioinformatics.

    REQUIREMENTS

    • Master's degree in computational metabolomics, bioinformatics, or closely related area
    • At least 4 years of experience with analytics for metabolomics (mass spectrometry and/or NMR-based)
    • Competent in more than one programming language (e.g., C++, Perl, Python, Matlab, R, etc.)
    • Strong communication and writing skills; one should be able to easily communicate the technical solutions put forth to a non-technical audience.

    PREFERENCES

    • Experience collaborating with subject matter specialists in the general area of biomedical and biomolecular research.
    • PhD in computational metabolomics, bioinformatics, statistics or closely related area
    • 2-3 years of postdoctoral experience in a field combining computational and life sciences
    • Ability to assess resource requirements and use resources effectively

    TERMS

    Applicants must be eligible to work in the United States. All hires are subject to final budgetary approval.

    LOCALE

    Lincoln, Nebraska, USA

    COMPENSATION

    Negotiable

    HOW TO APPLY

    To view requirements and to apply for this position, go to the UNL Employment web site: employment.unl.edu. Search for requisition number S_170557. Click on "Apply to this job." Complete application. Attach a letter of interest, curriculum vitae, research and teaching statement (each limited to one page). Applicants must arrange for three letters of reference to be submitted by email to jclarke3[at]unl.edu.

    DEADLINE

    Review of applications begins October 1, 2017, and will continue until the position is filled or the search is closed

    POLICY

    The University of Nebraska‐Lincoln is committed to a pluralistic campus community through affirmative action, equal opportunity, work‐life balance, and dual careers. See www.unl.edu/equi[...]ation.

    BACKGROUND

    A Postdoc position is available in the Diaz laboratory, at the University of California, San Francisco (diazlab.ucsf.edu). Our lab applies single-cell profiling, genomics and other assays to clinical samples, to address problems in neuro-oncology and neuro-development.

    RESPONSIBILITIES

    The postdoc will develop statistical and computational tools, analyze, interpret and integrate single-cell and bulk 'omics data.

    REQUIREMENTS

    We are particularly interested in candidates with expertise in machine learning, distributed computing, data science, applied statistics and/or network hypothesis testing and graph analytics. The position requires a PhD in a quantitative discipline, and strong mathematics and programming skills. Previous experience in biology, bioinformatics and next-generation sequencing data analysis is preferred. But, applications from highly motivated candidates, with a strong background in some other area of data analysis and the ability to learn quickly, are also quite welcome.

    LOCALE

    San Francisco, CA

    HOW TO APPLY

    Interested candidates should send an email to aaron.diaz[at]ucsf.edu, with the following:
    • CV
    • Cover letter, detailing programming experience, knowledge of mathematics and statistics, and bioinformatics or other data analysis experience. Please indicate your preferred start date.
    • Names and contacts of three references

    Submitter

    Scientists argue that there is a need to have strong standards for p-value statistics to claim new discoveries.

    EXCERPT

    So, in a provocative manuscript posted on the PsyArXiv preprint server on 22 July, researchers argue that P-value thresholds should be lowered to 0.005 for the social and biomedical sciences (D. Benjamin et al. Preprint on PsyArXiv osf.io/prep[...]mky9j; 2017). The final paper is set to be published in Nature Human Behaviour.
    Source: www.nature.com/arti[...]190-5

     

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