[BiO BB] Reactome version 17 released!
Reactome-Knowledgebase at reactome.org
Reactome-Knowledgebase at reactome.org
Mon Apr 24 11:42:25 EDT 2006
The Reactome Knowledgebase group (Cold Spring Harbor Lab and the
European Bioinformatics Institute) is proud to announce the release
of Reactome Version 17 today, accessible at http://www.reactome.org!
Reactome is a curated knowledgebase of biological processes in
humans. It covers processes ranging from basic pathways of metabolism
to complex events such as hormonal signaling and apoptosis. The
information in Reactome is provided by expert bench biologists, and
edited and managed as a relational database by the Reactome staff.
New material is peer-reviewed and revised as necessary before
publication to the web. Reactome entries are linked to corresponding
ones in NCBI EntrezGene, RefSeq, OMIM, Ensembl genome annotations,
UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO).
New modules include signaling cascades mediated by TGF-beta, RIG-I,
and Toll-like receptors 3 and 4, the conjugation phase of
xenobiotic metabolism, aspects of the metabolism of lipoproteins,
cell cycle regulation by the anaphase-promoting complex (APC), and
ATR activation in response to replication stress. The total number of
curated human reactions in the knowledgebase is now 1828 and the
total number of annotated human proteins is 1369.
New software features in version 17 include an upgraded SkyPainter
tool, which now shows all reactions involving proteins in a user-
specified list highlighted on the Reactome reaction map, lists these
reactions in downloadable tabular form, and identifies pathways that
are statistically over-represented for a list of specified proteins.
As before, Reactome data can be exported in SMBL, Protégé, and BioPAX
level 2 formats.
Like everything in Reactome, these downloaded and exported materials
can be reused and redistributed freely. For questions and comments,
please reply to this message or write to help at reactome.org
-Reactome teams at CSHL and EBI
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