[BiO BB] How to calculate the value of k and lambda for calculating the expectation value?

[shohag md]

Hi everybody



After aligning two/more sequences I want to find the expectation value.

But for calculating the expectation value we know that there are two
constanats, k and lambda.(E= kmn e-lambda *s, where m and n are the lengths
of sequences)

Now I want to know how to calculate the value of k and lambda.

I want to know the mathematics , not any tool .



Are there any one who can help me?

Thanks in advance



shoyaib
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