[BiO BB] how to identify the function and structure of a novel sequence

[Li Xue]

hello all,

I have a novel sequence(the protein sequence, DNA sequence, the 
coding sequence, and the cDNA sequence).

I tried BLASTn, BLASTx, and PSI-BLAST with default parameters and 
modified parameters which loosed the restriction to try to find 
distantly related matches. What I got are only unknown sequences and 
hypothetical sequences.

I also tried EBI Interpro with default parameters. No hits.

Can someone offer some ways to identify the function and the 
structure of  a new sequence? Thank you.

Li