Some years back when Timelogic and Paracel were popular there were some discussions on FPGA based computing for Linux clusters. I can't recall if there was a general conclusion but one of the limitations was that you're stuck with the algorithms the manufacturer provided. SGI approached me recently to talk about their reconfigurable FPGA systems and I was intrigued. The new RASC allows a user to remap the FPGA according to your own algorithms instead of being limited to one set of libraries. They also link it with GNU tools for debugging etc. Has anyone looked at the SGI RASC or any other equivalent system out there? Any ideas if it makes sense in today's clusters? The workload I'm supporting has very few custom written algorithms and is mostly BLAST, phred/phrap, hmmer with some heavy Amber and Gromacs thrown in as well. TIA.