While we are on the discussion of clusters and development efforts for a variety of platforms, I found Warren Gish's comments on Mac OS X interesting. see http://blast.wustl.edu/blast/README.html#Platforms Can someone out there with a OS X machine see if it really is limited to 2 GB files? 32 bit file systems are a showstopper (as are 32 bit development architectures) for me. -- Joe Landman, email: landman at scientificappliance.com web : http://scientificappliance.com