While it is true that most bioinformaticians are tolerant of various language choices, there are good reasons to standardize on a small set of languages within any research group or institution---maintenance of code written in "unusual" languages is a major headache. I have a few TCL scripts written by a former student that cause more maintenance problems than 100x as many lines of perl code---even though the TCL is well written and much of the perl is not. The problem is that no one else here uses TCL, so making even trivial changes is a major undertaking. ------------------------------------------------------------ Kevin Karplus karplus at soe.ucsc.edu http://www.soe.ucsc.edu/~karplus Professor of Biomolecular Engineering, University of California, Santa Cruz Undergraduate and Graduate Director, Bioinformatics (Senior member, IEEE) (Board of Directors & Chair of Education Committee, ISCB) life member (LAB, Adventure Cycling, American Youth Hostels) Effective Cycling Instructor #218-ck (lapsed) Affiliations for identification only.