hello, i'm kevin hollevoet, thesisstudent at the university of Ghent (belgium) at the medical research building. we are planning to use meltsim to preform some large scale simulations to test the sensitivity of HRM towards single CpG's methylation differences in NB cell lines. but the problems we are facing are the same like Marko Pavlekovic wrote to you some time ago (for the record: i'm using window XP to run MELTSIM) so i tried, just like marko, to change all '.' into ','. even in the output files, when i only selected the meltcurse, the graph was not what i would expect. other options they gave also errors for the use of E09 (meaning 10^9) in the output file. and that fault (i dont even know what the fault is) is obviously not that easy to change in an output file. so is there already some other version on the market or the web? perhaps this is some european problem with the configuration of the windows XP here? as there are a lot of articles citing your program, even recently, it should work somehow perfectly well, no? greetings kevin