[meltsim] problem running MELSTIM

J.W. Bizzaro jeff at bioinformatics.org
Wed Aug 15 18:43:45 EDT 2007

Hi Kevin,

I started working on a PHP interface a couple years ago.  I set it up on the MeltSim website just now for anyone who'd like to use it:


Note that there may be some kinks in it.  On the back-end it's running version 1.99.0 (C/Linux), which is older and imperfect.  Also, I'm not sure if the web server will handle very large jobs from MeltSim: there's no scheduler in place for it, and MeltSim can be very compute intensive.  Try to keep the sequences under 10 kbp, especially if running a positional map.

Please report any problems that you or anyone else finds, and I'll add this interface to the source code in SVN, just as soon as it seems ready:



Kevin Hollevoet wrote:
> hello,
> i'm kevin hollevoet, thesisstudent at the university of Ghent (belgium) 
> at the medical research building. we are planning to use meltsim to 
> preform some large scale simulations to test the sensitivity of HRM 
> towards single CpG's methylation differences in NB cell lines.
> but the problems we are facing are the same like Marko Pavlekovic wrote 
> to you some time ago (for the record: i'm using window XP to run MELTSIM)
> so i tried, just like marko, to change all '.' into ','. even in the 
> output files,  when i only selected the meltcurse, the graph was not 
> what i would expect. other options they gave also errors for the use of 
> E09 (meaning 10^9) in the output file. and that fault (i dont even know 
> what the fault is) is obviously not that easy to change in an output file.
> so is there already some other version on the market or the web? perhaps 
> this is some european problem with the configuration of the windows XP 
> here? as there are a lot of articles citing your program, even recently, 
> it should work somehow perfectly well, no?
> greetings
> kevin

J.W. Bizzaro
Bioinformatics Organization, Inc. (Bioinformatics.Org)
E-mail: jeff at bioinformatics.org
Phone:  +1 508 890 8600

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