[Molvis-list] pdb files of wild type/mutants

Paul Pillot paul.pillot at wanadoo.fr
Mon May 9 07:07:50 EDT 2005

1j46 & 1j47 represent the hmg box portion of SRY protein. They only 
differ by 1 amino-acid, but the mutation causes a change in shape, 
making the protein unable to bend correctly the DNA in order to initiate 
the transcription.


Frieda Reichsman a écrit :

> Dear Colleagues,
> I am seeking pdb files to use as paired examples of the effects of a 
> single amino acid substitution on protein structure/function. Ideally 
> I would like to have some examples of substitutions that alter 
> function, and some that have little or no evident functional effect. 
> If both types of substitutions are available for the same protein, so 
> much the better.
> A good example is normal and sickle cell hemoglobin, but I would like 
> to have somewhere between four and ten different protein examples. I 
> need some that affect binding or enzymatic activity and are located in 
> the binding or active site.
> Thanks in advance for suggestions on this topic.
> Frieda

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