[Molvis-list] pdb files of wild type/mutants

David Fahrney dfahrney at lamar.colostate.edu
Fri May 6 17:59:04 EDT 2005


The Weizmann Institute of Science maintains an
excellent database of point mutations called


This databank provides PDB files of proteins which
differ by one or two amino acids. You can search
by protein name, PDB ID, etc.

Dave Fahrney
Professor of Biochemistry
Colorado State University

Frieda Reichsman wrote:
> Dear Colleagues,
> I am seeking pdb files to use as paired examples of the effects of a
> single amino acid substitution on protein structure/function. Ideally I
> would like to have some examples of substitutions that alter function,
> and some that have little or no evident functional effect. If both
> types of substitutions are available for the same protein, so much the
> better.
> A good example is normal and sickle cell hemoglobin, but I would like
> to have somewhere between four and ten different protein examples. I
> need some that affect binding or enzymatic activity and are located in
> the binding or active site.
> Thanks in advance for suggestions on this topic.
> Frieda
> Frieda Reichsman, PhD
> Molecules in Motion
> Interactive Molecular Structures
> www.moleculesinmotion.com
> MyDNA Project
> www.bio.umass.edu/biochem/mydna
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