(I'm back in touch with the world -- sorry for the absence) tools needed: -- device driver for Linux, FreeBSD, etc for ABI sequencers (not sure about this) -- "fuzzy" CLIPS-style inference engine for "expert" per-base decision-assistance -- a tutorial that's what my father said when I asked him what people want in a replacement for GCG-Wisc. (he has worked on the molecular genetics of childhood cancer for 20 years) In fact, the second item -- assistance in recognizing which type of NA a base is even when it looks like the peaks in the chromatogram could go either way -- is what he stated was missing in most commercial packages today. Basically, his conclusion was that many people dislike GCG and would switch if a better alternative was available (esp. one which could be extended/customized). Me personally, I'm still trying to understand all of this comparison-matrix stuff for searching. But it is very challenging (i.e. cool) and hopefully will be a good excuse for having written a simple parser-tokenizer for raw base-by-base sequences. Speaking of challenging, I have become a bit stumped with GTK. I still don't entirely understand how GTK is designed -- if the GTK gurus on this project were willing to offer some assistance, I might progress beyond simple "Sign your timecard today!" boxes that I run from cron twice a month. ;-) Part of this is that I'm a crappy C programmer and haven't applied myself to the tutorial, but when I follow along with the tutorial, I feel like I'm just going through the motions, rather than figuring out what's being designed. I also realized that (and this is probably irrelevant to TULIP, but still) I need someone academic and respected to goon for me if I am going to hold a real job yet stay involved in protein folding / nucleic acid folding for real. If anyone on this list knows such a person at UVM, Middlebury, Dartmouth, or UNH, please let me know; this is really important to me personally. My mailbox is full of TULIP messages -- I will now go read them. ps. What does that stand for? -- "We all enter this world in the same way: naked; screaming; soaked in blood. But if you live your life right, that kind of thing doesn't have to stop there." --Dana Gould