Below is part of a message I got yesterday... ------------------------------- I was looking at getting involved with Piper, since I like the idea of pipes for GUIs and multiplexing for CLI... We do a lot of population genetic data analysis that involves running various analysis programs on data, and "piping" it off into different programs, merging results etc, and also getting into <buzzword>"data mining"</buzzword>. Due to time constraints I've been hacking up some godawful shell and awk, but in the medium-to-long term, Piper, Python and such has to be the way to go. So I could act as a beta-tester/bug fixer/guinea pig project for Piper. I've been playing around a bit with hacking on GNOME programs, so I like the idea that you're using GNOME/CORBA as a foundation. Another project you maybe interested in, and is, at least conceptually, related to Piper, is IMT: http://sourceforge.net/projects/imt It's a simulation framework in XML that is designed to be a high-level glue that can bind different simulation frameworks together. In essence to provide an abstraction for mixing different layers such as "R", "Grass" (open source GIS), "GALib" (open source genetic algorithm library) and "Swarm" (open source discrete event/agent based modelling toolkit, which is the project I used to be employed to work on before I went back to grad school). It's a little different in that it was inspired more by simulation/modelling issues than bioinformatic/data analysis, but both IMT and Piper seem, in a broad sense to complement each other (or at least interoperate). I haven't worked on IMT, but I know all the people involved and my former Swarm colleague is working on the Swarm/IMT integration right on. Anyway, I mention all of this to give you an idea of my background and interests. The holy grail in all this is interoperability and seamlesness (as much as possible) between data and models in different knowledge domains, and most genomics/bioinformatics companies doing any kind of software seem hell-bent to reinvent as many wheels as possible and create a few Tower's of Babel in the process... So that's why the existence of the Open Lab, especially in the gold rush stampede mentality that so many companies and universities (sadly) seem to have for genomics these days, is such a vital thing.