[Proteopedia] AlphaFold2 continues to be the best
Eric Martz
m0lviz at yahoo.com
Wed Aug 16 19:47:30 EDT 2023
Every 2 years, there is an international competition (CASP) to see which
method can best predict protein structure from sequence. Predictions are
made for proteins whose empirically-determined structures will be
published later, but the predictors don't have access to those
structures when the predictions are made. In 2020 at CASP 14, DeepMind's
AlphaFold2 blew everyone away by predicting structures for most proteins
with accuracies nearly as good as empirical determinations.
The results of the 2022 CASP 15 have been coming out in publications
over recent months. AlphaFold2 continues to out-perform all other
methods for most sequences. There are now >200 million
AlphaFold2-predicted structures in its free database
(http://alphafold.ebi.ac.uk). (There are roughly 50,000
sequence-distinct proteins among the ~200,000 empirical structures in
the Protein Data Bank.) If your protein of interest is not in the
database, instructions on how to use free AlphaFold Colab to make
predictions are in Proteopedia:
https://proteopedia.org/w/How_to_predict_structures_with_AlphaFold
A one-paragraph summary of the results of CASP 15 is now available:
https://proteopedia.org/w/Theoretical_models#2022:_CASP_15
See also
https://proteopedia.org/w/AlphaFold
-Eric Martz
More information about the Proteopedialist-for-users
mailing list