| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Growth | c-MYC is involved in anchorage independent prostate cancer cell growth through regulating ezrin protein expression in an androgen dependent way. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Proliferation | c-MYC is involved in prostate cancer cell proliferation as targeted reduction of c-MYC results in suppression of cell proliferation in prostate cancer cell line LNCaP. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Genome Instability, Mutation & Perturbation | Overexpression | c-MYC located at 8q24 is overexpressed during prostate cancer development. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Genome Instability, Mutation & Perturbation | Overexpression | Nuclear MYC protein overexpression is an early alteration in human prostatecarcinogenesis. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metastasis | Cell Invasion | c-MYC is associated with prostate cancer cell invasion through regulating ezrin protein expression in an androgen dependent way. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metastasis | Epithelial Mesenchymal Transition(EMT) | c-MYC is involved in prostate cancer epithelial mesenchymal transition upon phosphorylation by ERK2. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Cell Death Resistance | Chemoresistance | c-Myc mediated signaling play an important role in docitaxel resistance in prostate cancer. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Cell Death Resistance | Chemoresistance | Hexosamine biosynthetic pathway (HBP) through O-linked beta-N-acetylglucosamine transferase (OGT) regulates the stability of c-MYC in prostate cancer. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Growth | Mediates prostate cancer cell growth regulation through interaction with ROCK in androgen independent prostate cancer cell line. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metabolic Reprogramming | Metabolic Reprogramming | Hexosamine biosynthetic pathway (HBP) modulates c-MYC stability, which plays a leading role in prostate cancer metabolic reprogramming. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metabolic Reprogramming | Metabolic Reprogramming | Sphingosine kinase 1(SK1) enhances c-MYC stability, whicg is essentially involved in prostate cancer warburg effect and cell survival. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metabolic Reprogramming | Metabolic Reprogramming | c-MYC activates metabolic sensor AMPK and thereby enhances glycolysis and consequently promotes metabolic reprogramming in prostate cancer. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Enabling Replicative Immortality | Telomere maintenance | c-MYC oncogene is significantly associated with stabilization of telomerase reverse transcriptase (hTERT) through up-regulation of hTERT expression in human prostate tumour cell. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Genome Instability, Mutation & Perturbation | Gene Amplification | c-MYC oncogene is amplified in human prostate cancer and plays a very important role in prostate cancer development and progression. | Reference |