Shape code- Hexagon depicts Adaptor protein, Round depicts-Receptor protein and Round Rectangle depicts other types of protein (e.g. Kinase etc). Color code- Red indicates positive perturbation, Green indicates negative perturbation and Yellow indicates no reported information associated with perturbation. Positive perturbation includes overexpression, amplification, up regulation and oncogenic activation (mutational activation). Negative perturbation includes deletion, loss of expression, genomic instability, epigenetic silencing, microRNA mediated silencing, aberrant splicing and down regulation. Edge represents physical interaction between two proteins as based on Human Reference Protein Database (HRPD) and literature mined information.
| Protein | Protein Name | Molecular Type |
|---|
| ADAM12 | ADAM metallopeptidase domain 12 | Metallo Protease |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | GTPase |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase |
| ANK1 | Ankyrin 1, erythrocytic | Adaptor Protein |
| APC | Adenomatous polyposis coli | Adhesion Molecule |
| AR | Androgen receptor | Nuclear Receptor |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Membrane transport protein |
| AXIN1 | Axin 1 | Adaptor Protein |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase |
| BAG3 | BCL2-associated athanogene 3 | Adaptor Protein |
| BAK1 | BCL2-antagonist/killer 1 | Adaptor Protein |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein |
| BCL2L1 | BCL2-like 1 | Adaptor Protein |
| BCL2L2 | BCL2-like 2 | Adaptor Protein |
| BECN1 | Beclin 1, autophagy related | Adaptor Protein |
| BIN1 | Bridging integrator 1 | Adaptor Protein |
| BIRC6 | Baculoviral IAP repeat containing 6 | Adaptor Protein |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase |
| CASP8 | Caspase 8, apoptosis-related cysteine peptidase | Cysteine Protease |
| CASP9 | Caspase 9, apoptosis-related cysteine peptidase | Cysteine Protease |
| CDK5 | Cyclin-dependent kinase 5 | Serine/Threonine Kinase |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein |
| CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Adhesion Molecule |
| CFLAR | CASP8 and FADD-like apoptosis regulator | Adaptor Protein |
| COMMD1 | Copper metabolism (Murr1) domain containing 1 | Unclassified |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | Adaptor Protein |
| CSF1R | Colony stimulating factor 1 receptor | Receptor Tyrosine Kinase |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein |
| DAXX | Death-domain associated protein | Adaptor Protein |
| DVL1 | Dishevelled segment polarity protein 1 | Adaptor Protein |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein |
| E2F1 | E2F transcription factor 1 | Transcription Factor |
| E2F2 | E2F transcription factor 2 | Transcription Factor |
| EEF1A1 | Eukaryotic translation elongation factor 1 alpha 1 | Transcription Regulatory Protein |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase |
| EPHB2 | EPH receptor B2 | Receptor Tyrosine Kinase |
| EPOR | Erythropoietin receptor | Cell Surface Receptor |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase |
| ESR1 | Estrogen receptor 1 | Transcription Factor |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein |
| FOXO1 | Forkhead box O1 | Transcription Factor |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein |
| FRS3 | Fibroblast growth factor receptor substrate 3 | Adaptor Protein |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase |
| GHR | Growth hormone receptor | Cell Surface Receptor |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein |
| GOLM1 | Golgi membrane protein 1 | Transport/Cargo Protein |
| GSK3B | Glycogen synthase kinase 3 beta | Serine/Threonine Kinase |
| HRK | Harakiri, BCL2 interacting protein | Adaptor Protein |
| HTRA2 | HtrA serine peptidase 2 | Serine Protease |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase |
| IL12A | Interleukin 12A | Cytokine |
| IL6ST | Interleukin 6 signal transducer | Cytokine Receptor |
| IMP3 | Insulin-like growth factor 2 mRNA binding protein 3 | Translation Regulatory Protein |
| IRS1 | Insulin receptor substrate 1 | Adaptor Protein |
| ITGB4 | Integrin, beta 4 | Adhesion Molecule |
| JAK2 | Janus kinase 2 | Tyrosine Kinase |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | GTPase |
| LPXN | Leupaxin | Adaptor Protein |
| LRP6 | low density lipoprotein receptor-related protein 6 | Structural Protein |
| MAP2K7 | Mitogen-activated protein kinase kinase 7 | Dual Specificity Kinase |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor |
| NOD1 | Nucleotide-binding oligomerization domain containing 1 | Adaptor Protein |
| NRBP1 | Nuclear receptor binding protein 1 | Adaptor Protein |
| NTRK1 | Neurotrophic tyrosine kinase, receptor, type 1 | Receptor Tyrosine Kinase |
| PABPC1 | Poly(A) binding protein, cytoplasmic 1 | RNA Binding Protein |
| PARD3 | Par-3 family cell polarity regulator | Adaptor Protein |
| PDE4D | Phosphodiesterase 4D, cAMP-specific | Enzyme Phosphodiesterase |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | Receptor Tyrosine Kinase |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase |
| PHB | Prohibitin | Adaptor Protein |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein |
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | Lipid Kinase |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein |
| PIM2 | Pim-2 oncogene | Serine/Threonine Kinase |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase |
| PRKCD | Protein kinase C, delta | Serine/Threonine Kinase |
| PRKCE | Protein kinase C, epsilon | Serine/Threonine Kinase |
| PRLR | Prolactin receptor | Receptor Tyrosine Kinase |
| PTK2B | Protein tyrosine kinase 2 beta | Tyrosine Kinase |
| PXN | Paxillin | Cytoskeletal Associated Protein |
| PYCARD | PYD and CARD domain containing | Adaptor Protein |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase |
| RAF1 | V-raf-1 murine leukemia viral oncogene homolog 1 | Serine/Threonine Kinase |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein |
| RET | Ret proto-oncogene | Receptor Tyrosine Kinase |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor |
| SHB | Src homology 2 domain containing adaptor protein B | Adaptor Protein |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | Adaptor Protein |
| SMAD2 | SMAD family member 2 | DNA Binding Protein |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein |
| SMAD4 | SMAD family member 4 | Transcription Factor |
| SMAD7 | SMAD family member 7 | Transcription Regulatory Protein |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | Ubiquitin Proteasome System Protein |
| SOCS1 | Suppressor of cytokine signaling 1 | Adaptor Protein |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein |
| SP1 | Sp1 transcription factor | Transcription Factor |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase |
| SRF | Serum response factor (c-fos serum response element-binding transcription factor) | Transcription Factor |
| ST7 | Suppression of tumorigenicity 7 | Cell Cycle Control Protein |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor |
| STAT5B | Signal transducer and activator of transcription 5B | Transcription Factor |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | Guanine Nucleotide Exchange Factor |
| TP53 | Tumor protein p53 | Transcription Factor |
| TRADD | TNFRSF1A-associated via death domain | Adaptor Protein |
| TYK2 | Tyrosine kinase 2 | Tyrosine Kinase |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor |
| WASF1 | WAS protein family, member 1 | Adaptor Protein |
| WASF3 | WAS protein family, member 3 | Cytoskeletal Associated Protein |
| WT1 | Wilms tumor 1 | Transcription Factor |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein |
| Protein | Protein Name | Molecular Type |
|---|
| 15-LOX2 | Arachidonate 15-lipoxygenase, type B | Enzyme |
| ABCA1 | ATP binding cassette subfamily A member 1 | Transport Protein |
| ABCB1 | ATP binding cassette subfamily B member 1 | Transport Protein |
| ACK1 | Tyrosine kinase, non-receptor, 2 | Tyrosine Kinase |
| ACO2 | Aconitase 2, mitochondrial | Enzyme |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | Enzyme |
| ADAM10 | ADAM metallopeptidase domain 10 | Metallo Protease |
| ADAM17 | ADAM metallopeptidase domain 17 | Metallo protease |
| ADAM9 | ADAM metallopeptidase domain 9 | Metallo protease |
| ADIPOQ | Adiponectin, C1Q and collagen domain containing | Secreted Polypeptide |
| ADRB2 | Adrenoceptor beta 2 | G protein Coupled Receptor |
| AGR2 | Anterior gradient 2, protein disulphide isomerase family member | Unclassified |
| AKR1C3 | Aldo-keto reductase family 1, member C3 | Enzyme |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | Serine/Threonine Kinase |
| ALDH1A2 | Aldehyde dehydrogenase 1 family member A2 | Enzyme |
| ANG | Angiogenin, ribonuclease, RNase A family, 5 | Enzyme |
| ANGPTL2 | Angiopoietin like 2 | Secreted polypeptide |
| ANXA1 | Annexin A1 | Calcium Binding Protein |
| AQP3 | Aquaporin 3 | Water Channel |
| AQP5 | Aquaporin 5 | Water Channel |
| ARA70 | Nuclear receptor coactivator 4 | Transcription Regulatory Protein |
| ARG1 | Arginase 1 | Enzyme |
| ARG2 | Arginase 2 | Enzyme |
| ARR2 | Arrestin, beta 2 | Adaptor protein |
| ARRB1 | Arrestin, beta 1 | Adaptor Protein |
| ATM | ATM serine/threonine kinase | Serine/Threonine Kinase |
| AURKA | Aurora kinase A | Serine/Threonine Kinase |
| B7H1 | CD274 molecule | Ligand |
| B7H3 | CD276 molecule | Ligand |
| BAG1 | BCL2 associated athanogene 1 | Transcription Factor |
| BIRC7 | Baculoviral IAP repeat containing 7 | Unclassified |
| BLT2 | Leukotriene B4 receptor 2 | G protein Coupled Receptor |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | DNA Binding Protein |
| BMP7 | Bone morphogenetic protein 7 | Ligand |
| BMX | BMX non-receptor tyrosine kinase | Tyrosine Kinase |
| BRCA1 | Breast cancer 1 | Transcription Regulatory Protein |
| BRCA2 | Breast cancer 2 | Transcription Regulatory Protein |
| BTK | Bruton agammaglobulinemia tyrosine kinase | Tyrosine Kinase |
| CACNA2D2 | Calcium channel, voltage-dependent, alpha 2/delta subunit 2 | Voltage gated channel |
| CADM2 | Cell adhesion molecule 2 | Adhesion Molecule |
| CAIX | Carbonic anhydrase IX | Enzyme |
| CAMK2N1 | Calcium/calmodulin-dependent protein kinase II inhibitor 1 | Unclassified |
| CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2, beta | Enzyme |
| CAV1 | Caveolin 1, caveolae protein, 22kDa | Structural Protein |
| CCL5 | C-C motif chemokine ligand 5 | Chemokine |
| CD147 | Basigin (Ok blood group) | Cell Surface Receptor |
| CD44 | CD44 molecule | Cell Surface Receptor |
| CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | Cell Junction Protein |
| CDK1 | Cyclin-dependent kinase 1 | Serine/Threonine Kinase |
| CDK6 | Cyclin-dependent kinase 6 | Cell Cycle Control Protein |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | Cell Cycle Control Protein |
| CEA | Carcinoembryonic antigen related cell adhesion molecule 3 | Adhesion Molecule |
| CFD | Complement factor D (adipsin) | Enzyme |
| CHD1 | Chromodomain helicase DNA binding protein 1 | DNA Binding Protein |
| CHEK2 | Checkpoint kinase 2 | Serine/Threonine Kinase |
| COX2 | Prostaglandin-endoperoxide synthase 2 | Enzyme |
| cPAcP | Acid phosphatase, prostate | Acid Phosphatase |
| CSL | Chorionic somatomammotropin hormone-like 1 | Peptide Hormone |
| CTNND2 | Catenin delta 2 | Adhesion Molecule |
| CTSL | Cathepsin L | Cysteine protease |
| CUL1 | Cullin 1 | Ubiquitin proteasome system protein |
| CX3CL1 | Chemokine (C-X3-C motif) ligand 1 | Chemokine |
| CX3CR1 | Chemokine (C-X3-C motif) receptor 1 | G protein Coupled Receptor |
| CX43 | Gap junction protein alpha 1 | Membrane Transport protein |
| CXCL12 | Chemokine (C-X-C motif) ligand 12 | Chemokine |
| CXCL13 | Chemokine (C-X-C motif) ligand 13 | Chemokine |
| CXCL5 | C-X-C motif chemokine ligand 5 | Chemokine |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein |
| DAXX | Death-domain associated protein | Adaptor protein |
| DIAPH3 | Diaphanous-related formin 3 | Unclassified |
| DKK1 | Dickkopf WNT signaling pathway inhibitor 1 | Ligand |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | Enzyme |
| E2F4 | E2F transcription factor 4 | Transcription Factor |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | Extracellular Matrix Protein |
| EGR3 | Early growth response 3 | Transcription Factor |
| EIF3D | Eukaryotic translation initiation factor 3 subunit D | Translation Regulatory Protein |
| ELK1 | ELK1, member of ETS oncogene family | Transcription Factor |
| ELOVL7 | ELOVL fatty acid elongase 7 | Unclassified |
| eNOS | Nitric oxide synthase 3 | Enzyme |
| EPHA6 | EPH receptor A6 | Receptor Tyrosine Kinase |
| EPLIN | LIM domain and actin binding 1 | Cytoskeletal Protein |
| ERBB3 | Erb-b2 receptor tyrosine kinase 3 | Receptor Tyrosine Kinase |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | Transcription Factor |
| ESL-1 | E-selectin ligand 1 | Integral Membrane Protein |
| ESR2 | Estrogen receptor 2 (ER beta) | Transcription Factor |
| ESRRA | Estrogen-related receptor alpha | Transcription Regulatory Protein |
| ETS1 | ETS proto-oncogene 1 | Transcription Factor |
| EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit | Transcription Regulatory Protein |
| FABP4 | Fatty acid binding protein 4, adipocyte | Chaperone |
| FAK | Protein tyrosine kinase 2 | Tyrosine Kinase |
| FASN | Fatty acid synthase | Enzyme |
| FBXL4 | F-box and leucine rich repeat protein 4 | Ubiquitin proteasome system protein |
| FER | Fer (fps/fes related) tyrosine kinase | Tyrosine Kinase |
| FGF19 | Fibroblast growth factor 19 | Growth Factor |
| FGF8 | Fibroblast growth factor 8 | Growth Factor |
| FGF9 | Fibroblast growth factor 9 | Growth Factor |
| FN1 | Fibronectin 1 | Extracellular Matrix Protein |
| FN14 | Tumor necrosis factor receptor superfamily member 12A | Cell Surface Receptor |
| FOXA1 | Forkhead box A1 | Transcription Factor |
| FOXO3 | Forkhead box O3 | Transcription Factor |
| FRA-1 | FOS-like antigen 1 | Transcription Factor |
| FUS | FUS RNA binding protein | RNA binding protein |
| FZD4 | Frizzled class receptor 4 | G protein Coupled Receptor |
| FZD8 | Frizzled class receptor 8 | G protein coupled receptor |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | Unclassified |
| GDF15 | Growth differentiation factor 15 | Growth Factor |
| GSTP1 | Glutathione S-transferase pi 1 | Enzyme |
| HAMP | Hepcidin antimicrobial peptide | Unclassified |
| HDAC6 | Histone deacetylase 6 | Enzyme |
| HEC1 | NDC80 kinetochore complex component | Cell Cycle Control Protein |
| HES6 | Hes family bHLH transcription factor 6 | Transcription Regulatory Protein |
| HIC5 | Transforming growth factor beta 1 induced transcript 1 | Transcription Regulatory Protein |
| HIF1A | Hypoxia inducible factor 1, alpha subunit | Transcription Factor |
| HIF2A | Endothelial PAS domain protein 1 | Transcription Factor |
| HK2 | Hexokinase 2 | Enzyme |
| HLA1 | Major histocompatibility complex, class I, A | MHC Complex Protein |
| HMGA1 | High mobility group AT-hook 1 | DNA Binding Protein |
| HOOK3 | Hook microtubule-tethering protein 3 | Adaptor protein |
| HOXB13 | Homeobox B13 | Transcription Factor |
| HSD3B1 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Enzyme Isomerase |
| HSP90 | Heat shock protein 90kDa alpha (cytosolic), class A member 1 | Chaperone |
| ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | Transcription Regulatory Protein |
| IGFBP2 | Insulin like growth factor binding protein 2 | Secreted Polypeptide |
| IGFBP3 | Insulin like growth factor binding protein 3 | Growth Inhibitory Factor |
| IGFBP5 | Insulin like growth factor binding protein 5 | Adhesion Molecule |
| IL17 | Interleukin 17A | Cytokine |
| IL18BP | Interleukin 18 binding protein | Secreted Polypeptide |
| IL1A | Interleukin 1 alpha | Cytokine |
| IL6 | Interleukin 6 | Cytokine |
| IL6 | Interleukin 6 | Cytokine |
| IL6R | Interleukin 6 receptor | Cytokine Receptor |
| INS | Insulin | Growth Factor |
| INSR | Insulin Receptor | Receptor Tyrosine Kinase |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | Adaptor protein |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | GTPase activating protein |
| IRF8 | Interferon regulatory factor 8 | Transcription Factor |
| ITGB1 | Integrin subunit beta 1 | Cell Surface Receptor |
| JMJD1A | Lysine (K)-specific demethylase 3A | Unclassified |
| JUNB | Jun B proto-oncogene | Transcription Factor |
| KCNMA1 | Potassium channel, calcium activated large conductance subfamily M alpha, member 1 | Ion channel |
| KLF5 | Kruppel-like factor 5 (intestinal) | Transcription Factor |
| KLF6 | Kruppel-like factor 6 | Transcription Factor |
| KLHL20 | Kelch like family member 20 | Adaptor protein |
| KLK2 | kallikrein related peptidase 2 | Serine Protease |
| LAT1 | Solute carrier family 7 (amino acid transporter light chain, L system), member 5 | Transport/Cargo Protein |
| LAT3 | Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | Transport/Cargo Protein |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein |
| LDH5 | Lactate Dehydrogenase 5 | Enzyme |
| LGALS1 | Galectin 1 | Ligand |
| LGALS3BP | Lectin, galactoside-binding, soluble, 3 binding protein | Extracellular Matrix Protein |
| LIMK1 | LIM domain kinase 1 | Serine/Threonine Kinase |
| LMP2 | Proteasome subunit beta 9 | Transcription Regulatory Protein |
| LMP7 | Proteasome subunit beta 8 | Ubiquitin Proteasome System Protein |
| LOX | Lysyl oxidase | Enzyme |
| LPAR6 | Lysophosphatidic acid receptor 6 | G protein Coupled Receptor |
| LSD1 | Lysine (K)-specific demethylase 1A | Enzyme Deacetylase |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | Tyrosine Kinase |
| MAOA | Monoamine oxidase A | Enzyme: Oxidase |
| MAPK1 | Mitogen-activated protein kinase 1 | Serine/Threonine Kinase |
| MARCKS | Myristoylated alanine rich protein kinase C substrate | Cytoskeletal Protein |
| MCAM | Melanoma cell adhesion molecule | Adhesion Molecule |
| MCL1 | Myeloid cell leukemia 1 | Chaperone |
| MCM7 | Minichromosome maintenance complex component 7 | Enzyme DNA helicase |
| MCP1 | Monocyte chemotactic protein 1 | Chemokine |
| MCP1 | Chemokine (C-C motif) ligand 2 | Chemokine |
| MED1 | Mediator complex subunit 1 | Transcription Regulatory Protein |
| MED12 | Mediator complex subunit 12 | Transcription Regulatory Protein |
| MED15 | Mediator complex subunit 15 | Transcription Regulatory Protein |
| MID1 | Midline 1 | Ubiquitin proteasome system protein |
| MLCK | Myosin light chain kinase 2 | Serine/Threonine Kinase |
| MMP2 | Matrix metallopeptidase 2 | Metallo Protease |
| MMP9 | Matrix metallopeptidase 9 | Metallo Protease |
| MT1H | Metallothionein 1H | Unclassified |
| MTOR | Mechanistic target of rapamycin kinase | Cell Cycle Control Protein |
| MUC1 | Mucin 1, cell surface associated | Unclassified |
| NBN | Nibrin | DNA Repair protein |
| NCOA3 | Nuclear receptor coactivator 3 | Transcription Regulatory Protein |
| NDRG1 | N-myc downstream regulated 1 | Unclassified |
| NFKB1 | Nuclear factor kappa B subunit 1 | Transcription Factor |
| NKG2D | Killer cell lectin-like receptor subfamily K, member 1 | Cell Surface Receptor |
| NKX3-1 | NK3 homeobox 1 | Transcription Factor |
| NOS2 | Nitric oxide synthase 2, inducible | Unclassified |
| NOTCH1 | Notch 1 | Cell Surface Receptor |
| NR1H3 | Nuclear receptor subfamily 1 group H member 3 | Nuclear Receptor |
| NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Nuclear Receptor |
| NR5A1 | Nuclear receptor subfamily 5 group A member 1 | Nuclear Receptor |
| OLFM4 | Olfactomedin 4 | Unclassified |
| OPN | Osteopontin | Adhesion Molecule |
| P23 | Prostaglandin E synthase 3 (cytosolic) | Chaperone |
| P2X7 | Purinergic receptor P2X, ligand gated ion channel, 7 | Extracellular ligand gated channel |
| PAI1 | Serpin family E member 1 | Protease inhibitor |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | Serine/Threonine Kinase |
| PAR1 | Coagulation factor II (thrombin) receptor | G protein coupled receptor |
| PARM1 | Prostate androgen-regulated mucin-like protein 1 | Unclassified |
| PARP1 | Poly(ADP-ribose) polymerase 1 | Enzyme |
| PAX2 | Paired box 2 | Transcription Regulatory Protein |
| PAX6 | Paired box 6 | Transcription Factor |
| PCLP | Podocalyxin like | Integral Membrane Protein |
| PDE4B | Phosphodiesterase 4B | Enzyme |
| PDGFA | Platelet derived growth factor subunit A | Growth Factor |
| PGC1A | Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Transcription Regulatory Protein |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase |
| PIN1 | Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Enzyme |
| PINX1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | Unclassified |
| PIWIL2 | Piwi-like RNA-mediated gene silencing 2 | Transcription Regulatory Protein |
| PKIB | Protein kinase (cAMP-dependent, catalytic) inhibitor beta | Enzyme Regulator |
| PKM2 | Pyruvate kinase | Enzyme |
| PML | Promyelocytic leukemia | Transcription Regulatory Protein |
| POLK | Polymerase (DNA directed) kappa | DNA Binding Protein |
| POSTN | Periostin, osteoblast specific factor | Adhesion Molecule |
| PRDX3 | Peroxiredoxin 3 | Enzyme |
| PRKAR2A | Protein kinase, cAMP-dependent, regulatory subunit type II alpha | Serine/Threonine Kinase |
| PRL1 | Protein-tyrosine-phosphatase of regenerating liver 1 | Tyrosine Phosphatase |
| PSAP | Prosaposin | Integral Membrane Protein |
| PSGR | Prostate | G protein Coupled Receptor |
| PTEN | Phosphatase and tensin homolog | Lipid Phosphatase |
| PTH1R | Parathyroid hormone 1 receptor | G protein coupled receptor |
| PTHLH | Parathyroid hormone like hormone | Peptide Hormone |
| PTHRP | Parathyroid hormone like hormone | Peptide Hormone |
| PTK6 | Protein tyrosine kinase 6 | Tyrosine Kinase |
| PTP1B | Protein tyrosine phosphatase, non-receptor type 1 | Tyrosine Phosphatase |
| PTTG1 | Pituitary tumor-transforming 1 | Transcription Regulatory Protein |
| PYCR1 | Pyrroline-5-carboxylate reductase 1 | Enzyme |
| RANKL | Receptor activator of NF-?-B ligand | Ligand |
| RAP1A | RAP1A, member of RAS oncogene family | GTPase |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | Transcription Factor |
| RFWD2 | Ring finger and WD repeat domain 2, E3 ubiquitin protein ligase | Ubiquitin proteasome system protein |
| RLN2 | Relaxin 2 | Peptide Hormone |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | Serine/Threonine Kinase |
| RSK1 | Ribosomal protein S6 kinase, 90kDa, polypeptide 1 | Serine/Threonine Kinase |
| RUNX1 | Runt-related transcription factor 1 | Transcription Factor |
| SATB1 | SATB homeobox 1 | Transcription Factor |
| SELE | Selectin E | Adhesion Molecule |
| SERPINB5 | Serpin peptidase inhibitor, clade B (ovalbumin), member 5 | Protease inhibitor |
| SHH | Sonic hedgehog | Ligand |
| SIAH2 | Siah E3 ubiquitin protein ligase 2 | Unclassified |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | Ubiquitin Proteasome System Protein |
| SLC16A4 | Solute carrier family 16, member 4 | Transport Protein |
| SLC2A1 | Solute carrier family 2 (facilitated glucose transporter), member 1 | Transport protein |
| SNAIL | Snail family zinc finger 1 | Transcription Regulatory Protein |
| SND1 | Staphylococcal nuclease and tudor domain containing 1 | Transcription Regulatory Protein |
| SOD2 | Superoxide dismutase 2 | Enzyme |
| SOX2 | SRY-box 2 | Transcription Factor |
| SPAG9 | Sperm associated antigen 9 | Integral Membrane Protein |
| SPHK1 | Sphingosine kinase 1 | Lipid kinase |
| SPOP | Speckle type POZ protein | Transcription Regulatory Protein |
| SREBP1 | Sterol regulatory element binding transcription factor 1 | Transcription Factor |
| SRPK1 | SRSF protein kinase 1 | Dual Specificity Kinase |
| SSB | Sjogren syndrome antigen B (autoantigen La) | RNA Binding Protein |
| STAT5A | Signal transducer and activator of transcription 5A | Transcription Factor |
| STIM1 | Stromal interaction molecule 1 | Adhesion Molecule |
| STYK1 | Serine/threonine/tyrosine kinase 1 | Dual Specificity Kinase |
| TACC2 | Transforming, acidic coiled-coil containing protein 2 | Cell Cycle Control Protein |
| TAP1 | Transporter 1, ATP-binding cassette, sub-family B | Transport Protein |
| TAP2 | Transporter 2, ATP-binding cassette, sub-family B | Transport Protein |
| TBK1 | TANK binding kinase 1 | Serine/Threonine Kinase |
| TCTN1 | Tectonic family member 1 | Unclassified |
| TERT | Telomerase reverse transcriptase | Reverse Transcriptase |
| TGFB1 | Transforming growth factor, beta 1 | Ligand |
| TGFB2 | Transforming growth factor beta 2 | Growth Factor |
| TGFBI | Transforming growth factor beta induced | Ligand |
| TGFBR1 | Transforming growth factor beta receptor 1 | Receptor Serine/Threonine kinase |
| TGFBR3 | Transforming growth factor, beta receptor III | Cell Surface Receptor |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | Extracellular Matrix Protein |
| TIP60 | K(lysine) acetyltransferase 5 | Enzyme Acyltransferase |
| TLN1 | Talin 1 | Cytoskeletal associated protein |
| TLR4 | Toll-like receptor 4 | Cell Surface Receptor |
| TLX | Nuclear receptor subfamily 2, group E, member 1 | Nuclear Receptor |
| TNC | Troponin C type 1 (slow) | Calcium Binding Protein |
| TNFRSF12A | TNF receptor superfamily member 12A | Cell Surface Receptor |
| TNK2 | Tyrosine kinase, non-receptor, 2 | Tyrosine Kinase |
| TOP2A | Topoisomerase (DNA) II alpha | Enzyme |
| TRPM7 | Transient receptor potential cation channel, subfamily M, member 7 | Ion channel |
| TRPM8 | Transient receptor potential cation channel, subfamily M, member 8 | Intracellular Ligand Gated Channel |
| TSC1 | Tuberous sclerosis 1 | Cytoskeletal associated protein |
| TWEAK | TNF superfamily member 12 | Ligand |
| TWIST1 | Twist family bHLH transcription factor 1 | Transcription Factor |
| UBE2C | Ubiquitin conjugating enzyme E2C | Ubiquitin Proteasome System Protein |
| UBE2T | Ubiquitin conjugating enzyme E2T | Ubiquitin proteasome system protein |
| UPA | Plasminogen activator, urokinase | Serine Protease |
| VCL | Vinculin | Cytoskeletal associated protein |
| WNT7B | Wingless-type MMTV integration site family member 7B | Ligand |
| WWOX | WW domain containing oxidoreductase | Enzyme Oxidoreductase |
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | DNA Repair protein |
| YAP1 | Yes associated protein 1 | Transcription Regulatory Protein |
| YB1 | Y-box binding protein 1 | Transcription Factor |
| ZAP70 | Zeta chain of T cell receptor associated protein kinase 70kDa | Tyrosine Kinase |
| ZEB1 | Zinc finger E-box binding homeobox 1 | Transcription Factor |
