| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| TP53 | Tumor protein p53 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | TP53 functions as a tumour suppressor and suffers from mutation in prostate cancer. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | Tumour suppressor TP53 mutations in exon 7 and exon 8 are factors of tumor progression in PCa. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Genome Instability, Mutation & Perturbation | Mutation | TP53 mutation in exon7 and exon8 play an important role in prostate cancer development. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Genome Instability, Mutation & Perturbation | Genome Instability | identification of LOH in these patients suggests that the TP53 tumor suppressor gene may play a more active role in prostate cancer | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Genome Instability, Mutation & Perturbation | | sGCalpha1 overexpression causes cytoplasmic sequestration and inactivation of TP53 during prostate cancer development. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Metastasis | Metastasis | Loss of TP53 results in invasion and metastasis of prostate cancer mediated by FAK-Src signaling pathway. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Metastasis | Epithelial Mesenchymal Transition(EMT) | TP53 loss in prostate epithelial cell results in epithelial mesenchymal transition in prostate cancer. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Cell Death Resistance | Aoptosis Resistance | It is involved in the resistance to apoptotic cell death in both androgen dependent & independent prostate cancer cell line. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Metastasis | Epithelial Mesenchymal Transition(EMT) | Loss of TP53 enhances EMT and stemness of prostate cancer cells through partially through repressing miR-145. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Enabling Replicative Immortality | Senescence Downmodulation | Tumour suppressor p53, which is found completely lost during the progression of prostate cancer, plays a vital role in the induction of cellular senescence program. | Reference |