| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| FOXO1 | Forkhead box O1 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | Aberrant activation of CDK1 and CDK2 results in phosphorylation and inactivation of FOXO1, inhibiting its tumour suppressive function. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | FOXO1 play a crucial role in prostate cancer tumor suppression by acting as a key downstream effector of PTEN. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Survival | Its inactivation via CDK1 mediated phosphorylation enhances cell survival in androgen dependent prostate cancer cell line. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Proliferation | CDK1 play an important role in prostate cancer cell proliferation by phosphorylation and inhibition of tumour suppressor gene FOXO1. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | FOXO1A, which is downregulated in human prostate cancer, plays an important tumour suppressive role through inhibition of androgen receptor signaling and suppression of prostate cancer cell proliferation. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Metastasis | Cell Migration | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell migration. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Metastasis | Cell Proliferation | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell proliferation. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Metastasis | Cell Invasion | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell invasion. | Reference |