| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Growth | STAT3 mediates IL-6 induced growth inhibition in androgen dependent prostate cancer cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Growth | STAT3 is associated with prostate cancer cell growth as inhibition of STAT3 activity results in suppression of cell growth in DU145 prostate cancer cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Tumor Promoting Inflammation | Inflammation | STAT3 functions as an important regulator of pro carcinogenic prostatic inflammation. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Genome Instability, Mutation & Perturbation | Overexpression | STAT3 gene is overexpressed in human prostate cancer. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Angiogenesis | Angiogenesis | STAT3 is involved in prostate cancer angiogenesis by targeting VEGF, supported by experiments on hypoxic PC-3 cells.. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Metastasis | STAT3 is involved in the metastasis of prostate cancer through rearrangements of cytoplasmic actin stress fibers and microtubules | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Cell Invasion | STAT3 is involved in TGFbeta1 mediated prostate cancer invasion. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Cell Motility | Inhibition of the Jak2 tyrosine kinase results in activation of Stat3 and prostate cancer cell motility in both DU145 and PC-3 cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Cell Motility | STAT3 promotes prostate cancer cell motility through Integrin beta 6 mediated signaling. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Cell Motility | STAT3 promotes prostate cancer cell motility through JAK2/STAT3 signaling. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Cell Migration | high density lipoprotein (HDL) and sphingosine-1-phosphate (S1P) activates STAT3 via ERK1/2 and promotes prostate cancer cell migration. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Cell Migration | STAT3 is involved in IL-6 mediated cell migration in prostate cancer DU145 cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Enabling Replicative Immortality | Telomere maintenance | Activation of STAT3 results in enhancement of telomerase reverse transcriptase transcriptional activity in prostate cancer cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Avoidance of Immune Destruction | Immuno Suppression | Activation of STAT3 mediated signaling plays a crucial role in immune suppression in prostate cancer associated tumour microenvironment. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | Bone Metastasis | STAT3, a transcription factor which is overexpressed in bone metastatic prostate cancer cell and plays a role in prostate cancer bone metastasis by stimulating Cathepsin L synthesis through JAK2/STAT3 signaling axis. | Reference |