| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Insensitivity to Anti-Growth Signal | Tumor Suppression | RB1 function as a tumour suppressor gene in prostate cancer as RB1 loss induces E2F1 mediated deregulation of the AR locus. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Genome Instability, Mutation & Perturbation | Genome Instability | Loss of heterogygosity for RB1 gene is frequently observed in invasive prostate cancer and prostatic intraepithelial neoplasia (PIN). | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Genome Instability, Mutation & Perturbation | Epigenetic Silencing | In castration resistant prostate cancer, RB1 gene is frequently deleted and methylated. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Enabling Replicative Immortality | Senescence Downmodulation | Retinoblastoma 1(RB1), which is inactivated through downregulation of tumour suppressor MiR- 449a, promotes senescence down modulation in human prostate cancer cell. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Androgen Independence | Androgen Independence | Retinoblastoma1 (RB1), which is frequently inactivated during prostate cancer progression, plays a very significant role the development of androgen independent prostate cancer. | Reference |