| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Tumor Promoting Inflammation | Inflammation pathway | It is implicated in prostate cancer inflammatory pathway and its genetic polymorphism has been detected in Caucasian population. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Genome Instability, Mutation & Perturbation | Genetic polymorphism | PIK3R1 single neuceotide polymorphism associates with aggressive prostate cancer in Caucasian and African American men. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metastasis | Cell Motility | Promotes cell motility in a bradykinine responsive manner and through PI3K/AKT1 pathway. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metabolic Reprogramming | Metabolic Reprogramming | PI3K/AKT pathway plays an essential leading role in enhancing HIF1A expression in prostate cancer, which is a master transcription factor and inherently associated with prostate cancer warburg effect. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metabolic Reprogramming | Metabolic Reprogramming | PI3K/AKT pathway activation, due to inactivation of PTEN tumour suppressor, play an important role in overexpression of fatty acid synthase (FAS) in prostate cancer, which is the key metabolic enzyme in the synthesis of long chain saturated fatty acids. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metabolic Reprogramming | Metabolic Reprogramming | PI3K/AKT pathway activates bifunctional enzyme PFKFB2, which plays a critical role in glucose uptake and glucose-dependent lipid synthesis in human prostate cancer. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Castration Resistance | Castration Resistance | PI3K pathway activation (due to loss of PTEN tumour suppressor) along with its crosstalk with androgen receptor (AR) plays a very significant role in the development and progression of castration resistant prostate cancer (CRPC). | Reference |