| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Survival | Mediates prostate cancer cell survival through Akt; involved in suppression of apoptosis; mediates prosurvival signaling by neuroendocrine derived peptides. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | IGF1R is transcriptionally regualted by transcription factor Early Growth Response-1 (EGR-1) and is involved in prostate cancer cell growth. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | IGF-IR promotes prostate cancer growth by stabilizing alpha5beta1 integrin protein levels. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | IGF1R is involved in prostate cancer cell survival as siRNA mediated silencing of IGF1R results in reduction of cell survival in prostate cancer PC-3 cells. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | Overexpression | IGF1R is overexppressed in human prostate cancer. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Metastasis | Metastasis | IGF1R is involved in human prostate cancer metastasis through its effects on MT1-MMP. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Metastasis | Cell Motility | IGF1R is involved in androgen independent prostate cancer cell motility through modulation of alphavbeta3 integrin and PI3-K/Akt signaling pathway. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Metastasis | Cell Migration | IGF1R is involved in androgen independent prostate cancer cell migration through alphavbeta3 integrin and PI3-K/Akt signaling pathway. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Survival | Mediates prostate cancer prosurvival signaling by neuroendocrine derived peptides. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Enabling Replicative Immortality | Telomere maintenance | IGF1 plays a role in human prostate cancer by post translational modification of telomerase reverse transcriptase (hTERT) through IGF1R/PI3K/AKT1 signaling axis. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Androgen Receptor Signalling | AR Signaling | Insulin-like growth factor 1 receptor (IGF1R), which is overexpressed in human prostate cancer, plays a crucial role in prostate cancer cell survival through a ‘higher-level’ interaction between androgen receptor(AR). | Reference |