Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
EPHB2EPH receptor B2Receptor Tyrosine KinaseInsensitivity to Anti-Growth SignalTumor SuppressionEPHB2 is implicated as a prostate cancer tumour suppressor gene with somatic inactivating mutations occurring in ?10% of sporadic prostatic tumours.Reference
EPHB2EPH receptor B2Receptor Tyrosine KinaseSelf-Sufficiency in Growth SignalCell GrowthEPHB2 play an important roles in Prostate cancer cell growth as its transfection in DU 145 cells which lack the EPHB2 suppresses clonogenic growth.Reference
EPHB2EPH receptor B2Receptor Tyrosine KinaseGenome Instability, Mutation & PerturbationMutationFrameshift, splice site, missense and nonsense mutations are found in the EPHB2 gene in clinical prostate cancer samples.Reference

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