| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Tumour Microenvironment | Cancer Microenvironment | In the prostate cancer microenvironment and bone microenvironment PDGFRB mediated signaling in stroma play an important role in prostate cancer bone metastasis | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Survival | PDGFRB-MCL1 mediated survival signaling play an important role in prostate cancer cell survival. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | PDGFR is involved in prostate cancer cell growth as siRNA mediated silencing of PDGFRB in mouse model results in reduction of cell growth in prostate cancer. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Angiogenesis | Angiogenesis | PDGFRB mediated signaling promotes angiogenesis in prostate cancer. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Angiogenesis | Angiogenesis | siRNA mediated silencing of PDGFRB in mouse model results in significant reduction of microvessel density in prostate cancer. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Metastasis | Metastasis | Mutational inactivation of EPHB2 have an important functional consequence in prostate cancer metastasis. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Cell Death Resistance | Aoptosis Resistance | PDGFRB upregulates MCL1 through HIF1alpha and beta catenine mediated signaling and MCL1 is involved in docetaxel resistance in metastatic prostate cancer. | Reference |