| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | EGFR is associated with prostate cancer cell growth through both paracrine and autocrine manner. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | EGFR is involved in prostate cancer cell proliferation in an ADAM17 induced and EGFR/PI3K/AKT pathway. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | EGFR plays an important role in prostate cancer cell proliferation as microRNA targeting EGFR suppressed cell proliferation in androgen insensitive cell line PC3 and DU145. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | Gene Amplification | EGFR gene is amplification frequently in advanced hormone refractory prostate cancer. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | Overexpression | EGFR is overexpressed in prostatetumour and in prostate cancer cell line DU145. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | | Impaired endocytic downregulation of EGFR can also be accounted for its metastatic association in prostate cancer. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Cell Invasion | EGFR plays an important role in prostate cancer cell invasion as microRNA targeting EGFR suppressed cell invasion in androgen insensitive cell line PC3 and DU145. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Epithelial Mesenchymal Transition(EMT) | EGFR is involved in prostate cancer epithelial mesenchymal transition in a LIV-1 induced and ERK mediated signaling. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Cell Migration | EGFR is involved in prostate cancer cell migration through AKT dependent way. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Cell Migration | EGFR plays an important role in prostate cancer cell migration as microRNA targeting EGFR suppressed cell migration in androgen insensitive cell line PC3 and DU145. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Bone Metastasis | It is involved in prostate cancer bone metastasis through cell survival and regulation of bone remodeling. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Cell Death Resistance | Apoptosis Evasion | EGFR shows an important role in anoikis resistance in metastatic prostate cancer along with SRC. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Cell Motility | Promotes prostate cancer cell motility through AKT1. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Metastasis | Epithelial Mesenchymal Transition(EMT) | SPINK1, which is overexpressed in prostate cancer promotes EMT through EGFR signaling. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Castration Resistance | Castration Resistance | Epidermal growth factor receptor, which is overexpressed in human prostate cancer (due to loss of miR-146a), plays a very important role in castration resistant prostate cancer (CRPC) development. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Androgen Receptor Signalling | AR Signaling | EGFR plays a very crucial role in human prostate cancer progression through activation of androgen receptor (AR) mediated signaling through both PI3K/AKT & MAPK pathway and also by direct physical interaction with AR. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | Mutation | Somatic mutation in tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR) gene has been detected in chinese prostate cancer patients. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Cell Death Resistance | Chemoresistance | Epidermal growth factor receptor (EGFR), which is overexpressed in human prostate cancer, plays a role in the promotion of docetaxel resistance in castration resistant prostate cancer (CRPC) cell through AKT dependent expression of MDR1. | Reference |