Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorTumour MicroenvironmentCancer MicroenvironmentCXCL12/CXCR4 mediated signaling is associated with secretion of MM9 in the local microenvironmentReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorSelf-Sufficiency in Growth SignalCell GrowthCXCR4 antagonists inhibits tumour growth in PC-3 xenograft model by suppressing CXCR4 mediated signalingReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorSelf-Sufficiency in Growth SignalCell ProliferationCXCR4 mediated signaling is involved in prostate cancer epithelial cell proliferationReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorTumor Promoting InflammationHypoxiaCXCR4/SDF-1alpha is involved in reactive oxygen species(ROS) generation during prostate tumorigenesis through NADPH oxidase (NOX) family of enzymesReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorGenome Instability, Mutation & PerturbationOverexpressionCXCR4 overexpression is associated with prostate tumorigenesisReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorAngiogenesisAngiogenesisCXCL12/CXCR4 mediated signaling is involved in prostate cancer angiogenesisReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorAngiogenesisAngiogenesishigh levels of CXCL12 signals through CXCR4 and there by inhibits, PGK1,the 'angiogenic switch' and enhances angiogenesisReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorMetastasisMetastasisCXCL12/CXCR4 mediated signaling is involved in regulation of metastasis in prostate cancerReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorMetastasisMetastasisThrough up regulation of VEGF and MMP9, CXC4 mediates prostate cancer metastasisReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorMetastasisCell InvasionIt plays a role in SLUG mediated cell invasion in androgen independent prostate cancer cell line.Reference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorMetastasisCell AdhesionCXCR4 enhances prostate cancer cell migration through alpha5 and beta3 integrinsReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorMetastasisCell MigrationSLUG and CXCL12 enhances prostate cancer cell migration through CXCR4.Reference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorMetastasisCell ProliferationCXCR4 mediated signaling is involved in prostate cancer epithelial cell proliferationReference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorCastration ResistanceCastration ResistanceChemokine (C-X-C motif) receptor 4 (CXCR4) mediates castration resistant prostate cancer (CRPC) development through transactivation of androgen receptor (AR).Reference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorAndrogen Receptor SignallingAR SignalingCXCR4 plays a critical role in human prostate cancer associated cell proliferation through ligand independent transactivation of Reference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorAndrogen IndependenceAndrogen IndependenceCXCL12/CXCR4 axis is involved in androgen independent prostate cancer progression through mediating ligand independent activation of androgen receptor (outlaw activation).Reference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorCell Death ResistanceChemoresistanceCXCL12/CXCR4 signaling axis is critically involved in the acquisition of docetaxel resistance in human prostate cancer cell through PAK4-dependent activation of LIMK1.Reference

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