| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Insensitivity to Anti-Growth Signal | Tumor Suppression | CDKN1B (p27) located on chromosome 16q, functions as a tumour suppressor in prostate cancer due to allelic loss and LOH. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Insensitivity to Anti-Growth Signal | Cell Cycle | CDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Self-Sufficiency in Growth Signal | Cell Proliferation | CDKN1B(p27) is involved in androgen independent prostate cancer cell proliferation as SOX2 targets p27 and regulate prostate cancer cell proliferation. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Self-Sufficiency in Growth Signal | Cell Proliferation | Inhibition of FOXO3a-mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Metastasis | Cell Invasion | CDKN1B(p27) is associated with prostate cancer cell invasion as downregulation of p27(Kip1) by XMRV infection results in enhancement of cell invasion. | Reference |