Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1)Cell Cycle Control ProteinInsensitivity to Anti-Growth SignalTumor SuppressionCDKN1A (p21) acts as a tumour suppressor during prostate tumorigenesis because of promoter hypermethylation.Reference
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1)Cell Cycle Control ProteinInsensitivity to Anti-Growth SignalCell CycleCDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4.Reference
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1)Cell Cycle Control ProteinSelf-Sufficiency in Growth SignalCell GrowthCDKN1A(p21) is involved in prostate cancer cell growth as a downstream effector of PI3K-Akt cell growth survival pathway.Reference
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1)Cell Cycle Control ProteinSelf-Sufficiency in Growth SignalCell GrowthCDKN1A(p21) is involved in prostate cancer cell growth as Naftopidil, a selective alpha-1 adrenoceptor antagonist targets p21 inhibits the growth of PC-3 cells.Reference
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1)Cell Cycle Control ProteinGenome Instability, Mutation & PerturbationMethylationCDKN1A(p21) is inactivated in metastatic prostate cancer through promoter hypermethylation.Reference

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