| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Insensitivity to Anti-Growth Signal | Tumor Suppression | CDKN1A (p21) acts as a tumour suppressor during prostate tumorigenesis because of promoter hypermethylation. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Insensitivity to Anti-Growth Signal | Cell Cycle | CDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Self-Sufficiency in Growth Signal | Cell Growth | CDKN1A(p21) is involved in prostate cancer cell growth as a downstream effector of PI3K-Akt cell growth survival pathway. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Self-Sufficiency in Growth Signal | Cell Growth | CDKN1A(p21) is involved in prostate cancer cell growth as Naftopidil, a selective alpha-1 adrenoceptor antagonist targets p21 inhibits the growth of PC-3 cells. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Genome Instability, Mutation & Perturbation | Methylation | CDKN1A(p21) is inactivated in metastatic prostate cancer through promoter hypermethylation. | Reference |