Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseSelf-Sufficiency in Growth SignalCell SurvivalMAPK3(ERK1) is associated with prostate cancer cell survival through PKCepsilon/PKD3 pathway.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseSelf-Sufficiency in Growth SignalCell GrowthMAPK3(ERK1) is associated with prostate cancer cell growth through PKCepsilon/PKD3 pathway.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseSelf-Sufficiency in Growth SignalCell ProliferationMAPK3(ERK1) activation through PI3K mediated signaling play an important role in prostate cancer cell proliferation.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseAngiogenesisAngiogenesisMAPK3 is involved in prostate cancer angiogenesis in response of osteopontin/alphavbeta3 signaling pathway and mediates the expression of VEGF in androgen independent prostate cancer cell line.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseAngiogenesisAngiogenesismiR-21 induces prostate cancer angiogenesis through activation of ERK1/2 mediated signaling and enhancing HIF-1alpha and VEGF expression.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseMetastasisCell InvasionMAPK3(ERK1) activation is an important step in CXCL13-mediated prostate cancer cell invasion.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseMetastasisCell InvasionMAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell invasion.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseMetastasisCell MotilityMAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell motility.Reference
MAPK3Mitogen-activated protein kinase 3Serine/Threonine KinaseMetastasisCell MigrationMAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell migration.Reference

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