| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Insensitivity to Anti-Growth Signal | Cell Cycle | AKT1 mediates an enhancement of Skp2 expression and there by promotes p27 destruction, that results in prostate cancer cell cycle deregulation. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Insensitivity to Anti-Growth Signal | Cell Cycle | PI3K/AKT1 mediates prostate cancer cell cycle deregulation through the activation of AKT/mTOR/p70(S6K) signaling pathway | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Survival | AKT1 is involved in prostate cancer cell survival in a cholesterol responsive way. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | AKT1 is involved in prostate tumour cell growth as a downstream effector of CXCL12/CXCR4 mediated signaling in DU145 prostate cancer cell line. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | AKT1 play an important role in prostate cancer cell proliferation through EGF-EGFR & ERBB2 mediated signaling. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | AKT1 play an important role in prostate cancer cell proliferation through GAS6-AXL mediated signaling. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Angiogenesis | Angiogenesis | miR-21 induces prostate cancer angiogenesis through activation of AKT1 mediated signaling and enhancing HIF-1alpha and VEGF expression in androgen independent prostate cancer cell line. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Angiogenesis | Angiogenesis | PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metastasis | Cell Invasion | AKT1 is associated with prostate cancer cell invasion through the aberrant activation of PI3K-Akt pathway. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metastasis | Cell Invasion | AKT1 is involved in prostate cancer cell invasion in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metastasis | Cell Motility | AKT1 is involved in prostate cancer cell motility in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metastasis | Cell Migration | AKT1 is involved in prostate cancer trans endothelial migration in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metastasis | Cell Migration | PI3K/AKT1 pathway play an important role in prostate cancer cell migration through HGF/SF responsive way | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metastasis | Bone Metastasis | AKT1 is involved in prostate cancer bone metastasis in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Survival | It mediates prostate cancer cell survival in response of IGF1R. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metabolic Reprogramming | Metabolic Reprogramming | Activation of the AKT-mTORC1-4EBP1 axis, due to inactivation of PTEN tumour suppressor, mediates prostate cancer warburg effects by enhancing hexokinase 2 (HK2) expression. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Enabling Replicative Immortality | Telomere maintenance | AKT1 plays an important role in human prostate cancer by mediating posttranslational modification telomerase reverse transcriptase (hTERT) and there by promoting its nulear translocation. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Androgen Independence | Androgen Independence | AKT1 is involved in androgen independent prostate cancer cell prolliferation and cell adhesion, and there by mediates androgen independent prostate cancer progression. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Death Resistance | Radioresistance | PI3K/AKT1/mTOR, the most frequently activated signaling pathways in prostate cancer, plays a very important role in the acquisition of radiation resistance in prostate cancer cell. | Reference |