Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseInsensitivity to Anti-Growth SignalTumor SuppressionFYN functions as a prostate cancer tumour suppressor in the altered biochemical landscape of neoplastic transformation.Reference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseInsensitivity to Anti-Growth SignalTumor SuppressionFYN located at chromosome 6q21 play a tumour suppressive role during prostate cancer progression; suffers from chromosomal deletion & promoter hypermethylation..Reference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseSelf-Sufficiency in Growth SignalCell GrowthFYN play an important role in prostate cancer cell growth mediated by HGF/MET signaling axis.Reference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseSelf-Sufficiency in Growth SignalCell ProliferationFYN is involved in the prostate cancer cell proliferation through both integrin and receptor tyrosine kinase mediated manner.Reference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseGenome Instability, Mutation & PerturbationGenome InstabilityFYN is downregulated in prostate cancer by both chromosomal deletion and promoter hypermethylation, and therefore is a novel prostate tumor suppressor gene candidate.Reference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseGenome Instability, Mutation & PerturbationOverexpressionFYN is overexpressed during prostate cancer progression.Reference
FYNFYN oncogene related to SRC, FGR, YESTyrosine KinaseMetastasisCell MotilityFYN is involved in the prostate cancer cell motility through both integrin and receptor tyrosine kinase mediated manner.Reference

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