| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| PXN | Paxillin | Cytoskeletal Associated Protein | Self-Sufficiency in Growth Signal | Cell Proliferation | Paxillin(PXN) play an important role in both androgen and growth factor mediated cell proliferation by modulating ERK mediated signaling in both castration sensitive and castration resistant prostate cancer. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Metastasis | Cell Invasion | Paxillin(PXN) is involved in the prostate cancer cell invasion through FAK/src/paxillin/Rac/JNK signaling resulting in the activation of MMP-2 and MMP-9 in prostate cancer LNCaP cell line. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Metastasis | Cell Motility | Paxillin is involved in the prostate cancer cell motility in a GDF9 responsive way and SMAD dependent manner in PC-3 prostate cancer cell line. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Metastasis | Cell Adhesion | Paxillin is involved in the prostate cancer cell adhesion in a GDF9 responsive way and SMAD dependent manner in PC-3 prostate cancer cell line. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Metastasis | Cell Adhesion | Involved in the regulation of prostate cancer cell adhesion in a alpha2 integrin mediated manner through FAK/src/paxillin/Rac/JNK signaling in androgen independent cell line. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Insensitivity to Anti-Growth Signal | Cell Cycle | Paxillin, a cytoplasmic adaptor protein is significantly involved in prostate cancer cell cycle through regulating c-FOS and cyclin D1 expression. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Castration Resistance | Castration Resistance | Paxillin(PXN), a known cytoplasmic adaptor protein, plays a crucial regulatory role of growth factor mediated signaling pathways in the development of castration resistant prostate cancer (CRPC). | Reference |