| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| IL6 | Interleukin 6 | Cytokine | Metabolic Reprogramming | Metabolic Reprogramming | Nuclear accumulation of adaptor protein ARRB1 enhances psudohypoxia and metabolic reprogramming in prostate cancer; additionally it also regulates the expression of HIF1A, which is a master transcription factor and inherently associated with prostate cancer warburg effect. | Reference |
| IL6 | Interleukin 6 | Cytokine | Tumour Microenvironment | Cancer Microenvironment | IL-6 plays an important roles in prostate cancer associated fibroblast(CAF) activation. | Reference |
| IL6 | Interleukin 6 | Cytokine | Tumour Microenvironment | Cancer Microenvironment | IL-6 secreted by prostate cancer cell functions in a critical manner for the conversion of stromal fibroblast into prostate cancer associated fibroblast(CAF). | Reference |
| IL6 | Interleukin 6 | Cytokine | Castration Resistance | Castration Resistance | IL-6 plays a role in castration resistant prostate cancer (CRPC) development through mediating docetaxel resistance. | Reference |